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林产化学与工业

林产化学与工业 ›› 2015, Vol. 35 ›› Issue (4): 125-130.doi: 10.3969/j.issn.0253-2417.2015.04.020

• 研究报告 • 上一篇    下一篇

响应面法优化二氢杨梅素半合成杨梅素

刘同方, 于华忠, 陈雁梅, 王亭   

  1. 吉首大学 林产化工工程湖南省重点实验室, 湖南 张家界 427000
  • 收稿日期:2014-07-16 出版日期:2015-08-25 发布日期:2015-08-29
  • 通讯作者: 于华忠(1973—),男,副教授,研究领域为天然产物化学;E-mail:yuhuazhong.001@163.com。 E-mail:yuhuazhong.001@163.com
  • 作者简介:刘同方(1987—),男,安徽东至人,硕士生,主要从事林产化学加工工程研究工作
  • 基金资助:
    湖南省高校科技创新团队支持计划(湘教通(2010)212号)

Optimization of Semisynthetic Myricetin from Dihydromyricetion by Response Surface Process

LIU Tong-fang, YU Hua-zhong, CHEN Yan-mei, WANG Ting   

  1. Key Laboratory of Hunan Forest Products and Chemical Industry Engineering, Jishou University, Zhangjiajie 427000, China
  • Received:2014-07-16 Online:2015-08-25 Published:2015-08-29

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摘要： 以显齿蛇葡萄叶中含量丰富且易于提取的二氢杨梅素(DMY)为原料,半合成得到杨梅素(MYR)。产物经FI-IR, 1H NMR 和 13C NMR 结构鉴定,确认是杨梅素。在单因素试验的基础上,选取吡啶体积分数、料液比和反应温度为影响因子,以MYR得率作为响应值, 进行响应面分析(RSM)。结果表明,MYR的最佳合成工艺参数为:吡啶体积分数66.6%、反应温度90.4 ℃、料液比值为20.88时MYR得率为76.63%,与预测值76.48%的相对误差为0.19%。

关键词: 二氢杨梅素, 半合成, 杨梅素, 响应面分析

Abstract: Dihydromyricetion(DMY), which was abundant and easily extracted from the leaves of Ampelopsis grossedentata, was used as the semisynthetic sources for myricetin(MYR). The structure of MYR was characterized by IR, 1H NMR and 13C NMR. Based on the results of the single factor experiments, response surface methodology(RSM) was applied to further optimize the synthesis conditions with pyridine volume fraction, and temperature, solid-liquid-ratio as the impact factors and MYR yield as the response value. The most suitable synthesis conditions of MYR were determined as follows: pyridine volume fraction 66.6%, temperature 90.4 ℃ and solid-liquid ratio 20.88(g:L). The MYR yield was 76.63%, and the relative error with the predictive value of 76.48% was 0.19%.

Key words: dihydromyricetion, semisynthetic, myricetin, response surface methodology

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