pH敏感型葡萄糖基水凝胶的制备及溶胀性能测试

doi:10.3969/j.issn.0253-2417.2016.04.010

林产化学与工业 ›› 2016, Vol. 36 ›› Issue (4): 73-78.doi: 10.3969/j.issn.0253-2417.2016.04.010

pH敏感型葡萄糖基水凝胶的制备及溶胀性能测试

林艳, 房桂干

中国林业科学研究院林产化学工业研究所;生物质化学利用国家工程实验室;国家林业局林产化学工程重点开放性实验室;江苏省生物质能源与材料重点实验室, 江苏南京 210042

收稿日期:2015-07-17 出版日期:2016-08-25 发布日期:2016-09-01
通讯作者: 房桂干,男,研究员,博士生导师,长期从事清洁制浆和生物质利用研究;E-mail:fangguigan@icifp.cn。 E-mail:fangguigan@icifp.cn
作者简介:林艳(1985-),女,湖北仙桃人,助理研究员,博士,主要从事生物质资源利用及功能材料开发研究
基金资助:
江苏省生物质能源与材料重点实验室一般项目资助（JSBEM-S-201510）

Preparation and Swelling Property of pH-Sensitive Glucose-based Hydrogels

LIN Yan, FANG Gui-gan

Institute of Chemical Industry of Forestry Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. of Forest Chemical Engineering, SFA;Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China

Received:2015-07-17 Online:2016-08-25 Published:2016-09-01

摘要/Abstract

摘要： 以葡萄糖为模板化合物，利用甲基丙烯酸缩水甘油醚对其改性后与丙烯酸、丙烯酰胺进行共聚反应，再经冷冻干燥，制备了具有pH值敏感特性的葡聚糖基水凝胶，并表征了其结构，优化了制备条件。结果表明：最佳条件为葡萄糖/丙烯酸/丙烯酰胺质量比为1：4：4，交联剂用量0.5%，引发剂用量1%，反应温度为65℃，在此条件下，水凝胶的平衡溶胀度可达90.5 g/g。研究发现该葡聚糖基水凝胶在同一pH值介质中的溶胀度随时间延长而增大，最后趋于平衡；其在无酶人工肠液（pH值7.4）中的溶胀度明显高于无酶人工胃液（pH值1.2），且该凝胶在两种介质中基本无降解。

关键词: 水凝胶, pH响应, 葡萄糖, 溶胀性能

Abstract: Glucose, as the template compound, was modified by glycidyl methacrylate and copolymerized with acrylic acid and acrylamide. After freeze drying, the pH-sensitive glulose-based hydrogels were obtained. The experimental conditions were studied and the optimal conditions were the 1:4:4 mass ratio of glucose/acrylic acid/acrylic amide, the 0.5% dosage of cross-linking agent, initiator and reaction temperature at 65℃. And the swelling ratio of hydrogel obtained under these conditions was about 90.5 g/g. Additionally, it was found that the swelling ratio of the glulose-based hydrogel increased with time extension and finally approached equilibrium in certain pH medium. And the swelling ratio of the hydrogels in the intestinal fluid without enzymes (pH=7.4) was significantly higher than that in the gastric fluid without enzymes (pH=1.2). Moreover, the hydrogels could keep basically no degradation in the two kinds of medium. This showed certain application prospect in tissue engineering materials.

Key words: hydrogels, pH-sensitive, glucose, swelling property

中图分类号:

TQ35
O629.12

林艳, 房桂干. pH敏感型葡萄糖基水凝胶的制备及溶胀性能测试[J]. 林产化学与工业, 2016, 36(4): 73-78.

LIN Yan, FANG Gui-gan. Preparation and Swelling Property of pH-Sensitive Glucose-based Hydrogels[J]. Chemistry and Industry of Forest Products, 2016, 36(4): 73-78.

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pH敏感型葡萄糖基水凝胶的制备及溶胀性能测试

Preparation and Swelling Property of pH-Sensitive Glucose-based Hydrogels

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