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林产化学与工业 ›› 2016, Vol. 36 ›› Issue (4): 140-146.doi: 10.3969/j.issn.0253-2417.2016.04.020

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长链燃料醇生物合成研究进展

许敬亮, 陈小燕, 肖仕圆, 袁振宏   

  1. 中国科学院可再生能源重点实验室;广东省新能源和可再生能源研究开发与应用重点实验室;中国科学院广州能源研究所, 广东 广州 510640
  • 收稿日期:2015-08-02 出版日期:2016-08-25 发布日期:2016-09-01
  • 作者简介:许敬亮(1977-),男,河南南阳人,研究员,博士,主要从事燃料醇和酶工程技术开发研究;E-mail:xjl@ms.giec.ac.cn。
  • 基金资助:
    国家自然科学基金资助项目(21176237);国家863计划资助(2013AA065803);广东省科技攻关项目(2013B010403021)

Research Progress on Biosynthesis of Long Chain Fuel Alcohol

XU Jing-liang, CHEN Xiao-yan, XIAO Shi-yuan, YUAN Zhen-hong   

  1. Key Laboratory of Renewable Energy;Guangdong Key Laboratory of New and Renewable Energy Research and Development;Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640, China
  • Received:2015-08-02 Online:2016-08-25 Published:2016-09-01

摘要: 简单介绍了长链醇作为液体燃料的优良性能,综述了长链醇生物合成的3条主要途径(Ehrlich途径、非发酵途径和光合途径),并进一步从宿主菌株选择、耐受菌株选育、代谢通路疏通以及产醇工艺优化等方面概述了提高长链醇产量的方法,最后对长链醇未来的研发方向进行了展望。

关键词: 长链醇, 生物合成, α-酮酸, Ehrlich途径, 非发酵途径, 光合途径

Abstract: This paper briefly introduced the excellent properties of long chain alcohols as liquid fuels and reviewed the three main biosynthesis pathways of long chain alcohols, i.e., Ehrlich pathway, non-fermentation pathway and photosynthetic pathway. The methods of improving the yield of long chain alcohol were summarized, such as choice of host strains, screening and breeding of tolerant strains, reconstruction of metabolic pathway, and optimization of long chain alcohol production process. And the future development direction of long chain alcohol was also suggested.

Key words: long chain alcohol, biosynthesis, α-keto acid, Ehrlich pathway, non-fermentation pathway, photosynthetic pathway

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