雷公藤化学成分及其热稳定性研究

doi:10.3969/j.issn.0253-2417.2017.02.009

摘要/Abstract

摘要： 从雷公藤（Tripterygium wilfordii Hook. f.）的根中分离得到7个化合物，经 ¹H NMR、¹³C NMR 和MS鉴定为β-谷甾醇（1）、丁香醛（2）、雷公藤乙素（3）、3-羟基-1-（4-羟基-3-甲氧基苯基）丙酮（4）、5，5'-二甲氧基落叶松脂素（5）、新刺五加酚（6）和16-羟基山海棠酸-18-O-β-D-葡萄糖苷（7）。其中化合物2、4、5和6为首次从雷公藤属植物中分离得到。采用热重和差热分析技术研究了雷公藤乙素（3）、新刺五加酚（6）以及雷公藤活性成分雷公藤内酯甲和去甲泽拉木醛的热稳定性。结果表明：雷公藤乙素、新刺五加酚、雷公藤内酯甲和去甲泽拉木醛的热分解温度均大于200 ℃。结果可为雷公藤质量标准以及雷公藤煨制机理研究奠定基础。

关键词: 雷公藤, 化学成分, 热稳定性

Abstract: Seven compounds were isolated from the radix of Tripterygium wilfordii Hook. f.. Their structures were identified as β-sitosterol(1), syringaldehyde(2), tripdiolide(3), β-hydroxypropiovanillone(4), 5, 5'-dimethoxylariciresinol(5), neociwujiaphenol(6) and wilfordoside A(7). Compounds 2, 4, 5 and 6 were isolated from genus of T. wilfordii for the first time. Thermal decomposing curves of compounds 3, 6, wilforlide A and demethylzeylasteral were obtained in the nitrogen atmosphere by TG-DTG and DTA techniques. The results indicated that the four tested compounds should be stable under 200 ℃. This study could lay a foundation for the quality standard and roasting mechanism of T. wilfordii.

Key words: Tripterygium wilfordii, chemical constituent, thermal stability

中图分类号:

TQ35

刘建群, 伍秋珊, 余昭芬. 雷公藤化学成分及其热稳定性研究[J]. 林产化学与工业, 2017, 37(2): 72-78.

LIU Jianqun, WU Qiushan, YU Zhaofen. Chemical Constituents from Tripterygium wilfordii Hook. f. and Their Thermal Stability[J]. Chemistry and Industry of Forest Products, 2017, 37(2): 72-78.

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