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林产化学与工业 ›› 2019, Vol. 39 ›› Issue (6): 88-94.doi: 10.3969/j.issn.0253-2417.2019.06.012

• 研究报告 • 上一篇    下一篇

圆齿野鸦椿枝条化学成分及其抗炎活性研究

陈景新1(),詹玉莹1,陈燕1,徐会有1,邹双全2,倪林1,2,*()   

  1. 1. 福建农林大学 植物保护学院, 福建 福州 350002
    2. 自然生物资源保育利用福建省高校工程研究中心, 福建农林大学, 福建 福州 350002
  • 收稿日期:2019-06-03 出版日期:2019-12-28 发布日期:2019-12-21
  • 通讯作者: 倪林 E-mail:1336921733@qq.com;nilin_fjau@126.com
  • 作者简介:陈景新(1993—   ),男,内蒙古呼伦贝尔人,硕士生,主要从事天然药物化学研究; E-mail:1336921733@qq.com
  • 基金资助:
    国家自然科学基金资助项目(31700292)

Chemical Constituents and Anti-inflammatory Activity from the Twigs of Euscaphis konishii Hayata

Jingxin CHEN1(),Yuying ZHAN1,Yan CHEN1,Huiyou XU1,Shuangquan ZOU2,Lin NI1,2,*()   

  1. 1. College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    2. Fujian Colleges and Universities Engineering Research Institute of Conservation & Utilization of Natural Bioresources, Fujian Agriculture and Forestry University, Fuzhou 350002, China
  • Received:2019-06-03 Online:2019-12-28 Published:2019-12-21
  • Contact: Lin NI E-mail:1336921733@qq.com;nilin_fjau@126.com
  • Supported by:
    国家自然科学基金资助项目(31700292)

摘要:

对圆齿野鸦椿枝条化学成分进行研究,从中分离得到15个化合物,通过理化性质与波谱分析分别鉴定为1-(4-羟基-3-甲氧基苯基)-2[4-(4'-羟丙基)-2'-甲氧基苯氧基]-1,3-丙二醇(1),acernikol(2),罗汉松脂素-4-O-β-D-葡萄糖苷(3),罗汉松脂素-4'-O-β-D-葡萄糖苷(4),2-[4-(1-羟丙基)-3-甲氧基苯氧基]-1,3-丙二醇(5),5,7-二羟基-2-甲基色原酮(6),5,7-二羟基-2-甲基色原酮-6-C-β-D-葡萄糖苷(7),5,7-二羟基-2-甲基色原酮-8-C-β-D-葡萄糖苷(8),槲皮素-3-O-α-L-阿拉伯糖(9),没食子酸(10),4-羟基-3-甲氧基苯甲醛(11),硬脂酸(12),19α-羟基熊果酸(13),β-谷甾醇(14)和胡萝卜苷(15)。除化合物7、8、1415外,其他化合物均为首次从该属植物中分离得到。抗炎活性评价结果显示:当浓度为10 μmol/L时,化合物24对脂多糖诱导的小鼠巨噬细胞白介素-6的分泌抑制率分别为(63.4±7.1)%和(58.6±4.6)%,显示中等抑制活性,略低于阳性对照药地塞米松的(85.8±5.3)%。

关键词: 圆齿野鸦椿, 化学成分, 结构鉴定, 白介素-6

Abstract:

Fifteen compounds were isolated from the twigs of Euscaphis konishii Hayata.The structure of the compounds was identified by physico-chemical properties and spectral data, and the fifteen compounds were as follows:threo-1-(4-hdroxy-3-methoxyphenyl)-2[4-(4'-hydroxypropyl)-2'-methoxyphenoxy] -1, 3-propanediol(1), acernikol (2), nortrachelogenin-4-O-β-D-glucopyranoside (3), nortrachelogenin 4'-O-β-D-glucopyranoside (4), 2-[4-(1-hydroxypropyl)-3-methoxyphenoxy] -1, 3-propanediol (5), 5, 7-dihydroxy-2-methylchromanone (6), isobiflorin (7), biflorin (8), quercetin-3-O-α-L-arabinose (9), gallic acid (10), 4-hydroxy-3-methoxy benzaldehyde (11), stearic acid (12), 19α-hydroxy ursolic acid (13), β-sitosterol (14), daucosterol (15).All compounds except 7, 8, 14, 15 were isolated from the plants of the genus E. konishii for the first time.The evaluation results of anti-inflammatory activity showed that the inhibition rates of lipopolysaccharide-induced murine IL-6 secretion by compound 2 and 4 were (63.4±7.1)% and (58.6±4.6)%, respectively, at the concentration of 10 μmol/L.The medium inhibitory activity was shown to be slightly lower than that of the positive control drug dexamethasone.

Key words: Euscaphis konishii Hayata, chemical constituents, structures identification, IL-6

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