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林产化学与工业 ›› 2022, Vol. 42 ›› Issue (4): 95-100.doi: 10.3969/j.issn.0253-2417.2022.04.014

• 研究报告 • 上一篇    下一篇

白背清风藤的三萜类化学成分研究

朱丽丽(), 钟林静, 徐梦娟, 陈俊锟, 梁林富()   

  1. 中南林业科技大学 材料科学与工程学院, 湖南 长沙 410004
  • 收稿日期:2021-05-28 出版日期:2022-08-28 发布日期:2022-09-01
  • 通讯作者: 梁林富 E-mail:593815441@qq.com;lianglinfu@aliyun.com
  • 作者简介:梁林富,副教授,硕士生导师,主要从事海洋及林源本草的研究与利用;E-mail: lianglinfu@aliyun.com
    朱丽丽(1995—),女,广西玉林人,硕士生,主要从事天然产物化学研究工作;E-mail: 593815441@qq.com
  • 基金资助:
    国家自然科学基金资助项目(41876194)

Chemical Constituents of Triterpenes from Sabia discolor Dunn

Lili ZHU(), Linjing ZHONG, Mengjuan XU, Junkun CHEN, Linfu LIANG()   

  1. College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China
  • Received:2021-05-28 Online:2022-08-28 Published:2022-09-01
  • Contact: Linfu LIANG E-mail:593815441@qq.com;lianglinfu@aliyun.com

摘要:

利用硅胶、Sephadex LH-20等柱层析分离技术,对白背清风藤茎干的乙醇提取物进行分离纯化,借助现代波谱技术(MS、1H NMR及13C NMR)鉴定化合物的结构。从白背清风藤茎干中分离得到10个五环三萜类化合物,鉴定为:20-羟基-3-羽扇豆酮(1)、羽扇豆烷-3β, 20-二醇(2)、(20S)-羟基-3-蒲公英酮(3)、3α, 28-二羟基-20-蒲公英烯(4)、蒲公英烷-3β, 20β-二醇(5)、齐墩果酸(6)、1-氧代-高根二醇(7)、山胡桃素A(8)、印度锥栗醇(9)和1α, 3β-二羟基-12-烯-28-齐墩果酸(10)。化合物24789为首次从清风藤属植物中分离得到,化合物13510为首次从该植物中分离得到。

关键词: 白背清风藤, 五环三萜, 齐墩果酸, 蒲公英烷-3β, 20β-二醇

Abstract:

The ethanol extracts from the stem of Sabia discolor Dunn were isolated and purified by silica gel and Sephadex LH-20 column chromatography. The structures of the compounds were verified by modern spectroscopy(MS, 1H NMR, 13C NMR). Ten pentacyclic triterpenoids were isolated from the stem of S. discolor, and identified as 20-hydroxy-lupan-3-one(1), monogynol A(2), (20S)-3-oxo-20-hydroxytaraxastane(3), 20-taraxastene-3α, 28-diol(4), 3β, 20β-dihydroxytaraxastane(5), oleanolic acid(6), 1-oxo-erythrodiol(7), juglangenin A(8), castanopsol(9) and 1α, 3β-dihydroxyl-olean-12-en-28-oic acid(10), respectively. Among them, compounds 2, 4, 7, 8 and 9 were obtained from the genus Sabia for the first time, and compounds 1, 3, 5 and 10 were isolated from this plant for the first time.

Key words: Sabia discolor Dunn, pentacyclic triterpenes, oleanolic acid, 3β, 20β-dihydroxytaraxastane

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