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林产化学与工业 ›› 2015, Vol. 35 ›› Issue (1): 23-29.doi: 10.3969/j.issn.0253-2417.2015.01.004

• 研究报告 • 上一篇    下一篇

cellulose-g-PMMA的合成及其胶束作为药物载体的研究

钟黎黎, 高源, 张力平   

  1. 北京林业大学 材料科学与技术学院, 北京 100083
  • 收稿日期:2013-12-31 出版日期:2015-02-25 发布日期:2015-03-05
  • 通讯作者: 张力平,女,教授,博士生导师,研究领域为功能高分子材料、生物质资源利用及生物质材料;E-mail:zhanglp418@163.com。 E-mail:zhanglp418@163.com
  • 作者简介:钟黎黎(1990-),女,四川绵阳人,硕士生,研究方向为功能高分子材料;E-mail:jongyeotoo@163.com
  • 基金资助:
    高等学校博士学科点专项(20110014110012)

Synthesis of Cellulose-g-PMMA and Its Micelles Using as Drug Carriers

ZHONG Li-li, GAO Yuan, ZHANG Li-ping   

  1. College of Material Science and Technology, Beijing Forestry University, Beijing 100083, China
  • Received:2013-12-31 Online:2015-02-25 Published:2015-03-05

摘要: 以纤维素为原料,离子液体为反应介质,首先制备了纤维素氯乙酸酯大分子引发剂,然后以甲基丙烯酸甲酯(MMA)为单体,纤维素氯乙酸酯/CuBr/2,2-联吡啶为引发体系,进行了原子转移自由基聚合反应,合成了纤维素接枝甲基丙烯酸甲酯聚合物(cellulose-g-PMMA)。利用傅里叶变换红外光谱、X射线衍射、热重分析等对cellulose-g-PMMA的结构与性能进行了表征。纤维素的结晶度57.90%,cellulose-g-PMMA的结晶度降至38.39%。利用原子力显微镜观察到cellulose-g-PMMA在溶剂丙酮中的平均粒径在40~70 nm左右。利用透射电镜观察到该聚合物胶束呈圆球状分布,粒径在200 nm左右,具有内核-外壳结构。以阿司匹林作为模型药物负载于聚合物胶束内,探讨了纤维素改性程度对药物释放率的影响。在37℃时,接枝反应3 h得到的cellulose-g-PMMA作为药物载体释放药物72 h后,释药率可达88.9%,具有较好释药效果。

关键词: 纤维素, 离子液体, 原子转移自由基聚合法, 药物载体

Abstract: Cellulose chloracetate, as a macromolecular initiator, was prepared by using cellulose as raw material, and ionic liquid as the reaction medium. Then, it was used for atom transfer radical polymerization to prepare cellulose-g-polymethyl methacrylate (cellulose-g-PMMA) using methyl methacrylate (MMA) as monomer and cellulose ester/CuBr/2,2-bipyridyl as the initiator system. The cellulose-g-PMMA was characterized by FT-IR, XRD, TGA and so on. The crystalline degree of cellulose is 57.9%, and fall to 38.39% by chemical modification. In the selective solvent acetone, the average particle diameter of the product was about 40-70 nm. TEM images showed that the copolymer micelles was spherical shape and the particle size was about 200 nm with core-shell structure. Aspirin was used as a model drug loading in the copolymer micelles to investigate the influence of the degree of cellulose modification on drug release efficiency. Drug release time of the cellulose-g-PMMA obtained by grafted polymerization for 3 h had 88.9% drug release rate after 72 h at 37℃. This cellulose-g-PMMA exhibited a good effect on drug release.

Key words: cellulose, ionic liquid, atom transfer radical polymerization (ATRP), drug carrier

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