油橄榄羟基酪醇的生物合成及其衍生物研究进展

doi:10.3969/j.issn.0253-2417.2015.02.024

摘要/Abstract

摘要： 介绍了传统化学合成羟基酪醇的方法,针对化学合成反应步骤多、催化剂昂贵、产率低、污染大等问题,重点总结了以橄榄苦苷和酪醇为原料生物法合成羟基酪醇的途径,同时还综述了羟基酪醇烷基醚、脂肪酸酯、糖基化等衍生物的制备方法、生物活性及其构效关系,为羟基酪醇及其衍生物批量制备及其抗肿瘤、抗癌、心脑血管疾病新药的筛选提供参考和指导作用。

关键词: 羟基酪醇, 羟基酪醇烷基醚, 羟基酪醇糖苷, 脂肪酸酯, 生物转化

Abstract: Chemical syntheses of hydroxytyrosol from different materials were investigated. Its disadvantages included long route, the low yield of product, and expensive catalyst as well as toxic reactants,etc.. This paper emphatically summarized biological synthetic routes for hydroxytyrosol with oleuropein and tyrosol. Furthermore, the syntheses and biological activities of hydroxytyrosol alkyl ether, lipophilic fatty acid ester, and glucoside derivatives, and structure-activity relationship were introduced. It is important to further study the syntheses of hydroxytyrosol and derivatives, and exploit new medicine of anti-tumor, anticancer, cardiovascular and cerebrovascular diseases.

Key words: hydroxytyrosol, alkyl ether, lipophilic fatty acid ester, glucosylated derivatives, biological transformation

中图分类号:

TQ35

原姣姣, 叶建中, 王成章, 鲁黎. 油橄榄羟基酪醇的生物合成及其衍生物研究进展[J]. 林产化学与工业, 2015, 35(2): 154-162.

YUAN Jiao-jiao, YE Jian-zhong, WANG Cheng-zhang, LU Li. Advance in Biosyntheses and Biological Activities of Olive Hydroxytyrosol and Its Derivatives[J]. Chemistry and Industry of Forest Products, 2015, 35(2): 154-162.

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