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林产化学与工业 ›› 2018, Vol. 38 ›› Issue (3): 25-32.doi: 10.3969/j.issn.0253-2417.2018.03.003

• 研究报告 • 上一篇    下一篇

松香基聚丙烯酰胺水凝胶的药物释放性能及其动力学研究

张海波1,2, 蒋建新2, 高宏1, 商士斌1, 宋湛谦1   

  1. 1. 中国林业科学研究院 林产化学工业研究所;生物质化学利用国家工程实验室;国家林业局 林产化学工程重点开放性实验室;江苏省 生物质能源与材料重点实验室, 江苏 南京 210042;
    2. 北京林业大学 材料科学与技术学院, 北京 100083
  • 收稿日期:2017-11-07 出版日期:2018-06-25 发布日期:2018-06-22
  • 通讯作者: 商士斌,研究员,博士生导师,从事生物质资源的化学研究与利用;E-mail:shangsb@hotmail.com。 E-mail:shangsb@hotmail.com
  • 作者简介:张海波(1989-),男,山东菏泽人,博士生,研究方向:生物质化学与利用;E-mail:shdzhanghaibo@163.com
  • 基金资助:
    国家自然科学基金资助项目(31470597);中国林科院林产化学工业研究所研究团队建设创新工程项目资助(LHSXKQ1)

Drug Release and Kinetics Properties of Rosin-based Polyacrylamide Hydrogels

ZHANG Haibo1,2, JIANG Jianxin2, GAO Hong1, SHANG Shibin1, SONG Zhanqian1   

  1. 1. Institute of Chemical Industry of Forest Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. of Forest Chemical Engineering, SFA;Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China;
    2. College of Materails Science and Technology, Beijing Forestry University, Beijing 100083, China
  • Received:2017-11-07 Online:2018-06-25 Published:2018-06-22

摘要: 以双氯芬酸钠、环丙沙星、茶碱为模型药,研究了松香基聚丙烯酰胺水凝胶的药物释放性能及其释放动力学,结果显示:水凝胶的平衡溶胀率随着松香基交联剂FPA-PEG200-AC用量增加而减小,在pH值7.4磷酸缓冲溶液中最大(12 g/g),去离子水中次之,pH值1.4盐酸溶液中最小;FPA-PEG200-AC用量为0.020 g/mL时,水凝胶对药物负载率最大(10.7%~16.6%)。不同交联剂用量制备的水凝胶的药物释放性能研究结果显示:双氯芬酸钠释放主要集中在1 h内,在3 h内累计释放率基本达到最大值;环丙沙星释放缓慢,8 h后累计释放率达到最大,FPA-PEG200-AC添加量为0.025 g/mL制备的水凝胶对环丙沙星的累计释放率最大,约为99.7%,茶碱在pH值7.4磷酸缓冲液中最大累计释放率均可达到99%,比在pH值1.4盐酸溶液中的累计释放率高。水凝胶的释放动力学模型主要为Higuchi模型(r2为0.873~0.999)和Korsmeyer-Peppas模型(r2为0.887~0.999,扩散指数n<0.5,为Fick扩散);当FPA-PEG200-AC用量为0.020、0.030 g/mL时,水凝胶对3种药物的释放机理均为Higuchi模型。

关键词: 松香, 水凝胶, 溶胀, 药物释放, 动力学

Abstract: Diclofenac sodium, ciprofloxacin and theophylline were used as model drugs to study the drug release properties and kinetics of rosin-based polyacrylamide hydrogels. The results indicated that the equilibrium swelling ratios of hydrogels decreased with the increase of the amount of rosin-based cross-linking agent FPA-PEG200-AC. And the equilibrium swelling ratio was largest(12 g/g) in the pH 7.4 PBS buffer solution, followed by the deionized water and it was the smallest in the pH 1.4 hydrochloric acid solution. The drug release properties of hydrogels prepared with different amounts of cross-linking agent showed that the diclofenac sodium was mainly released within 1 h, and reached the maximum values of cumulative release within 3 h. The ciprofloxacin was released slowly and reached the maximum values of cumulative release within 8 h; when the amount of FPA-PEG200-AC was 0.025 g/mL in hydrogel, the maximum values of cumulative release was about 99.7%. The maximum values of theophylline release in pH 7.4 PBS buffer could reach 99%, which was higher than the cumulative release rate in pH 1.4 hydrochloric acid solution. The drug release data of hydrogels were fitted into Higuchi models (r2=0.873-0.999) and Korsmeyer-Peppas models (r2=0.887-0.999, the diffusional exponent n< 0.5, Fick diffusion); the drug release of hydrogels was best explained by Higuchi models when the dosage of FPA-PEG200-AC was 0.020 and 0.030 g/mL.

Key words: rosin, hydrogels, swelling, drug release, kinetics

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