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林产化学与工业 ›› 2021, Vol. 41 ›› Issue (4): 29-34.doi: 10.3969/j.issn.0253-2417.2021.04.005

• 重点研发专栏 • 上一篇    下一篇

高效分离杉木精油中柏木醇的研究

潘洁尘1,2, 汤一川4, 束成杰2, 石宝俊1,2,*(), 朱凯3, 李伟1   

  1. 1. 南京中医药大学 药学院, 江苏 南京 210023
    2. 南京野生植物综合利用研究所, 江苏 南京 211100
    3. 南京林业大学, 江苏 南京 210037
    4. 南京中医药大学针灸推拿学院·养生康复学院, 江苏 南京 210029
  • 收稿日期:2020-11-17 出版日期:2021-08-28 发布日期:2021-08-31
  • 通讯作者: 石宝俊 E-mail:jacksonshi@126.com
  • 作者简介:石宝俊, 副研究员, 硕士生导师, 研究方向为植物精油的开发与利用; E-mail: jacksonshi@126.com
    潘洁尘(1996-), 女, 江苏无锡人, 硕士生, 主要从事中药分析及化学研究工作
  • 基金资助:
    国家重点研发计划资助项目(2018YFD0600405)

High Efficient Separation of Cedrol from Chinese Fir Essential Oil

Jiechen PAN1,2, Yichuan TANG4, Chengjie SHU2, Baojun SHI1,2,*(), Kai ZHU3, Wei LI1   

  1. 1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Nanjing Institute for Comprehensive Utilization of Wild Plants, Nanjing 211100, China
    3. Nanjing Forestry University, Nanjing 210037, China
    4. College of Acupuncture and Tuina, Nanjing University of Chinese Medicine, Nanjing 210029, China
  • Received:2020-11-17 Online:2021-08-28 Published:2021-08-31
  • Contact: Baojun SHI E-mail:jacksonshi@126.com

摘要:

利用减压精馏技术从杉木油中初步分离轻、重组分,再采用冷冻结晶的方法分离出柏木醇,GC/MS联用分析分离物中的柏木醇含量,确定最优工艺。通过研究减压精馏过程中不同回流比和全回流时间对收集的馏分中柏木醇的含量的影响,最终确定减压精馏条件为:在2~3 kPa条件下,全回流1 h,回流比值3~7时,柏木醇质量分数最高为97.89%,回收率为87.52%。将收集的柏木醇最高馏分用乙醇溶解、冷冻结晶,最终柏木醇纯度达到98.43%,回收率83.61%。

关键词: 杉木精油, 减压精馏, 冷冻结晶, 柏木醇, 高效分离

Abstract:

The light and heavy components were preliminarily separated from the cedar oil by vacuum distillation technology, and then the cedrol was separated by the method of freezing crystallization. The cedrol content in the isolate was analyzed by GC/MS to determine the optimal process. By studying the effects of different reflux ratio and total reflux time in the vacuum distillation process on the content of cedrol in the collected fractions, the final determination of vacuum distillation conditions were 2-3 kPa, total reflux time for 1h, reflux ratio of 3-7, the highest mass fraction of cedrol was 97.89%, the recovery rate was 87.52%. The collected highest fraction of cedrol was dissolved in ethanol, and then frozen and crystallized, and the purity of cedrol was finally reached 98.43%, the recovery rate was 83.61%.

Key words: Chinese fir essential oil, vacuum distillation, frozen and crystallized, cedrol, efficient separation

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