植物聚戊烯醇的化学修饰及药用剂型的研究进展

doi:10.3969/j.issn.0253-2417.2022.05.018

林产化学与工业 ›› 2022, Vol. 42 ›› Issue (5): 137-146.doi: 10.3969/j.issn.0253-2417.2022.05.018

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植物聚戊烯醇的化学修饰及药用剂型的研究进展

袁花¹^,², 沈红¹^,², 颜洋洋¹^,², 张昌伟¹, 王成章¹^,*()

1. 中国林业科学研究院林产化学工业研究所；江苏省生物质能源与材料重点实验室；国家林业和草原局林产化学工程重点开放性实验室；林木生物质低碳高效利用国家工程研究中心，江苏南京 210042
2. 南京林业大学江苏省林业资源高效加工利用协同创新中心，江苏南京 210037

收稿日期:2021-05-06 出版日期:2022-10-28 发布日期:2022-11-02
通讯作者: 王成章 E-mail:wangczlhs@sina.com
作者简介:王成章，研究员，博士生导师，研究领域为天然产物研究与利用；E-mail: wangczlhs@sina.com
袁花(1995—), 女，贵州毕节人，博士生，主要从事提取物化学与利用研究工作
基金资助:
国家自然科学基金资助项目(32101473);中国林科院中央级公益性科研院所基本科研业务费专项资金(CAFYBB2020SY039);江苏省生物质能源与材料重点实验室基本科研业务费项目(JSBEM-S-202008)

Review on Structure Modification and Pharmaceutical Formulations of Plant Ployprenol

Hua YUAN¹^,², Hong SHEN¹^,², Yangyang YAN¹^,², Changwei ZHANG¹, Chengzhang WANG¹^,*()

1. Institute of Chemical Industry of Forest Products, CAF; Key Lab. of Biomass Energy and Material, Jiangsu Province; Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration; National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass, Nanjing 210042, China
2. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China

Received:2021-05-06 Online:2022-10-28 Published:2022-11-02
Contact: Chengzhang WANG E-mail:wangczlhs@sina.com

摘要/Abstract

摘要：

植物聚戊烯醇是一类天然的类酯化合物，具有抗癌、保肝以及抗病毒等良好的生物活性。但由于聚戊烯醇疏水性较强，导致其在人体内的生物利用度低。针对植物聚戊烯醇含有多个非共轭双键和末端羟基结构特征，总结了聚戊烯醇加氢、氧化、酯化、胺化、烷基化以及格式反应等化学修饰的研究进展，介绍了具有代表性的系列聚戊烯醇衍生物及其生物活性，并重点综述了基于植物聚戊烯醇及其衍生物设计的纳米乳液、脂质体和注射剂等药用剂型最新进展，为进一步研究聚戊烯醇及其衍生物的药品开发提供参考。

关键词: 植物聚戊烯醇, 聚戊烯醇衍生物, 结构修饰, 药理活性

Abstract:

Plant polyprenols were a class of natural compound of esters with good biological activity, such as anticancer, hepatoprotective and antiviral. However, the strong hydrophobic of polyprenols resulted in the low bioavailability in the human body. In view of the structural characteristics of plant polyprenols containing multiple unconjugated double bonds and terminal hydroxyl groups, the research progress of polyprenols chemical modifications, such as addition, oxidation, esterification, amination, alkylation and grignard reaction were summarized, and a series of representative polyprenols derivatives and their biological activities were introduced. Meanwhile, the latest design and development of nanoemulsions, liposomes and injections based on plant polyprenols and their derivatives were reviewed, which provide a reference for further research into the development of pharmaceutical drugs of polyprenols and their derivatives.

Key words: plant ployprenol, ployprenol derivatives, structural modification, pharmacological activity

中图分类号:

TQ35

袁花, 沈红, 颜洋洋, 张昌伟, 王成章. 植物聚戊烯醇的化学修饰及药用剂型的研究进展[J]. 林产化学与工业, 2022, 42(5): 137-146.

Hua YUAN, Hong SHEN, Yangyang YAN, Changwei ZHANG, Chengzhang WANG. Review on Structure Modification and Pharmaceutical Formulations of Plant Ployprenol[J]. Chemistry and Industry of Forest Products, 2022, 42(5): 137-146.

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结构类型 structure type	结构式 structure	主要分布及链长 main distribution and chain length
茄尼醇 solanesol		茄科植物(n=6-9) solanaceae
桦木醇 betulaprenol		裸子植物(12≤ n≤120) gymnosperm
菲卡醇 ficaprenol		被子植物(n=6-40) angiosperm

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植物聚戊烯醇的化学修饰及药用剂型的研究进展

Review on Structure Modification and Pharmaceutical Formulations of Plant Ployprenol

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