磁性聚N-异丙基丙烯酰胺-聚丙烯酸纳米复合微球的制备与性能研究

doi:10.3969/j.issn.0253-2417.2014.01.004

Chemistry and Industry of Forest Products ›› 2014, Vol. 34 ›› Issue (1): 19-24.doi: 10.3969/j.issn.0253-2417.2014.01.004

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Preparation and Characterization of Magnetic Poly (N-isopr-opylacrylamide)-poly (Acrylic Acid) Hybrid Nanospheres

NAN Jing-ya¹, CHEN Ying^1,2, WANG Chun-peng^1,2, CHU Fu-xiang³

1. Institute of Chemical Industry of Forest Products, CAF; National Engineering Lab.for Biomass Chemical Utilization; Key and Open Lab.of Forest Chemical Engineering, SFA; Key Lab.of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China;
2. Institute of New Technology of Forestry, CAF, Beijing 100091, China;
3. Chinese Academy of Forestry, Beijing 100091, China

Received:2013-01-05 Online:2014-02-25 Published:2014-03-05

Abstract

Abstract: In this study, a convenient approach has been proposed for the preparation of magnetic poly (N-isopropylacrylamide)-poly (acrylic acid) (PNIPAm-PAA) hybrid nanospheres. In the first step, hollow PNIPAm-PAA nanocapules, of which the diameter was about 500 nm, were synthesized by precipitation polymerization with hydropropylcellulose-poly (acrylic acid) (HPC-PAA) particles as the template. In the second step, the electrostatic interaction self-assembly method and the in situ reduction method were adopted to generate the magnetic Fe₃O₄ nanoparticles inside the nanocpsules. Thus the magnetic Fe₃O₄/PNIPAm-PAA hybrid nanospheres were finally obtained and the average diameter was 400 nm. In addition, a high drug loading capacity and a sustained-release behavior were presented by using anti-cancer drug Doxorubicin hydrochloride (Dox) as a hydrophilic model drug. It indicated that the Fe₃O₄/PNIPAm-PAA hybrid nanospheres might be used as a new magnetic-targeted drug carrier for the drug delivery system.

Key words: poly (N-isopropylacrylamide), poly (acrylic acid), nanocapules, magnetic hybrid nanospheres, targeted drug carrier

CLC Number:

TQ35

NAN Jing-ya, CHEN Ying, WANG Chun-peng, CHU Fu-xiang. Preparation and Characterization of Magnetic Poly (N-isopr-opylacrylamide)-poly (Acrylic Acid) Hybrid Nanospheres[J]. Chemistry and Industry of Forest Products, 2014, 34(1): 19-24.

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Preparation and Characterization of Magnetic Poly (N-isopr-opylacrylamide)-poly (Acrylic Acid) Hybrid Nanospheres

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