丙烯海松酸及其噻二唑衍生物的制备及抑菌活性

doi:10.3969/j.issn.0253-2417.2014.03.010

Abstract

Abstract: Acrylpimaric acid was prepared from rosin through Diels-Alder addition reaction, and then a series of thiadiazole derivatives from acrylpimaric acid were synthesized. Acrylpimaric Acid and its thiadiazole structures were characterized by IR, ¹H NMR, MS, and elemental analysis. The antibacterial activities of these newly synthesized derivatives against Gram-negative bacteria and Gram-positive bacteria were also investigated. The results indicated that these compounds displayed extensive anti-bacterial activity against Gram-negative bacteria and gram-positive bacteria. Especially, compound 5f exhibited excellent antibacterial activity against Escherichia coli than bromogeramine. Compared with bromo-geramine (128 mg/L), compound 5f (64 mg/L) possessed a lower MIC value.

Key words: rosin, acrylpimaric acid, thiadiazole, antibacterial activity

CLC Number:

TQ351

LI Jian, RAO Xiao-ping, SONG Zhan-qian, XIAO Guo-min, SHANG Shi-bin. Synthesis and Antibacterial Activity of Acrylpimaric Acid and Its Thiadiazole Derivatives[J]. Chemistry and Industry of Forest Products, 2014, 34(3): 55-59.

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Synthesis and Antibacterial Activity of Acrylpimaric Acid and Its Thiadiazole Derivatives

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