氧化铝-重铬酸钾催化氧化桦木醇合成桦木酸

doi:10.3969/j.issn.0253-2417.2015.05.018

Abstract

Abstract: Betulonic acid was synthesized from betulin by catalytic oxidation using alumina-potassium dichromate as catalyst. The product was identified by FT-IR, ¹H NMR and HPLC. The synthetic conditions were optimized by single-factor experiment. The results were the molar ratio of oxidizing agent to betulin 3:1, reaction time 1.5 h, room temperature, and molar ratio of catalyst to oxidizing agent 4:1. Under these conditions, the productivity of betulonic acid was 83.02%. Target compand, betulonic acid was obtained with the yield of 67.25%, and the purity of the refined betulinic acid was 98.3%.

Key words: betulinic acid, catalysis on alumina, betulin, betulonic acid

CLC Number:

TQ35
TQ216

XIE Yang, LI Peng, YANG Fan, FU Dong, SUI Xin, ZHANG Hong-wei. Preparation of Betulinic Acid by Catalytic Oxidation of Betulin Using Alumina-potassium Dichromate as Catalyst[J]. Chemistry and Industry of Forest Products, 2015, 35(5): 111-115.

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Preparation of Betulinic Acid by Catalytic Oxidation of Betulin Using Alumina-potassium Dichromate as Catalyst

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