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Chemistry and Industry of Forest Products ›› 2015, Vol. 35 ›› Issue (6): 69-77.doi: 10.3969/j.issn.0253-2417.2015.06.012

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Synthesis and Antifungal Activity of CamphoricAcid-based Thiourea Derivatives

MA Xian-li1,2, LIU Lu-zhi1, DUAN Wen-gui1, SHI Xian-chun1, LI Fang-yao1,2, HUA Zhong-ze1   

  1. 1. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China;
    2. School of Pharmacy, Guilin Medical University, Guilin 541004, China
  • Received:2014-12-08 Online:2015-12-25 Published:2015-12-28

Abstract: Ten novel camphoric acid-based thiourea compounds (5a-5j) were prepared using camphoric acid and aminoethyl substituted phenyl thioureas as starting materials.The target compounds were characterized by FT-IR, 1H NMR, 13C NMR, LC-MS, and elemental analysis.The antifungal activities of the compounds 5a-5j were tested.The preliminary bioassay showed that most of the target compounds exhibited certain antifungal activities, in which camphoric acid-based (o-methoxy)phenyl thiourea 5c (R=o-CH3O) and camphoric acid-based (m-methoxy)phenyl thiourea 5d (R=m-CH3O) had inhibition rate of 86.9 % against Alternaria solani, and camphoric acid-based (m-methoxy)phenyl thiourea 5d, camphoric acid-based (m-methyl)phenyl thiourea 5g (R=m-CH3) and camphoric acid-based (p-bromo)phenyl thiourea 4i (R=p-Br) had inhibition rate of 86.1 % against Physalospora piricola at the concentration of 50 mg/L.In addition, compound 5i also had the best inhibitory activity against cercospora arachidicola(73.6%).

Key words: camphoric acid, thiourea, synthesis, antifungal activity

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