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Chemistry and Industry of Forest Products ›› 2016, Vol. 36 ›› Issue (2): 109-114.doi: 10.3969/j.issn.0253-2417.2016.02.016

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Preparation and Characterization of Curcumin Nanosuspensions

ZHANG Sheng-wei1, LI Xiang-zhou1,3, LI Wen-sheng1,2, GU Sheng-hua1   

  1. 1. College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China;
    2. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China;
    3. State Engineering Laboratory of Ecological Applied Technology in Forest Area of South China, Changsha 410004, China
  • Received:2015-01-23 Online:2016-04-25 Published:2016-04-26

Abstract: In order to improve the water solubility of curcumin, curcumin nanosuspensions were prepared by high pressure homogenization technology, and the preparation process was optimized.The physicochemical properties and chemical structure of curcumin nanosuspensions were investigated by UV spectrometry, infrared spectrometry (IR), X-ray diffractometry (XRD), transmission electron microscopy (TEM) and high performance liquid chromatography (HPLC). The results showed that the mean particle size of curcumin nanosuspension was (171.00±8.56)nm, and the PI was (0.69±0.05) under optimal conditions of 100 MPa and 30 cycles. UV, IR, XRD,TEM and HPLC results showed that the chemical structures of curcumin nanosuspensions were not obviously changed, the curcumin nanoparticles were irregular spherical form, and the crystallinity decreased. The water solubilities of curcumin nanopowder were 62.85 mg/L enhanced by 90.48 times compared with curcumin powder. The dissolution velocities were significantly improved, and the dissolution rate reached up to 80% at the time of 120 min. The research indicated that high pressure homogenization technology could be successfully used to prepare curcumin nanosuspensions.

Key words: curcumin nanosuspensions, high pressure homogenization, physicochemical property, preparation, characterization

CLC Number: