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Chemistry and Industry of Forest Products ›› 2016, Vol. 36 ›› Issue (4): 73-78.doi: 10.3969/j.issn.0253-2417.2016.04.010

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Preparation and Swelling Property of pH-Sensitive Glucose-based Hydrogels

LIN Yan, FANG Gui-gan   

  1. Institute of Chemical Industry of Forestry Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. of Forest Chemical Engineering, SFA;Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China
  • Received:2015-07-17 Online:2016-08-25 Published:2016-09-01

Abstract: Glucose, as the template compound, was modified by glycidyl methacrylate and copolymerized with acrylic acid and acrylamide. After freeze drying, the pH-sensitive glulose-based hydrogels were obtained. The experimental conditions were studied and the optimal conditions were the 1:4:4 mass ratio of glucose/acrylic acid/acrylic amide, the 0.5% dosage of cross-linking agent, initiator and reaction temperature at 65℃. And the swelling ratio of hydrogel obtained under these conditions was about 90.5 g/g. Additionally, it was found that the swelling ratio of the glulose-based hydrogel increased with time extension and finally approached equilibrium in certain pH medium. And the swelling ratio of the hydrogels in the intestinal fluid without enzymes (pH=7.4) was significantly higher than that in the gastric fluid without enzymes (pH=1.2). Moreover, the hydrogels could keep basically no degradation in the two kinds of medium. This showed certain application prospect in tissue engineering materials.

Key words: hydrogels, pH-sensitive, glucose, swelling property

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