银杏叶聚戊烯醇纳米乳液联合抗生素抗菌活性研究

doi:10.3969/j.issn.0253-2417.2017.01.010

Abstract

Abstract: The synergistic antibacterial effects of Ginkgo biloba leaves polyprenols nanoemulsion (GBP) combined with five types of antibiotics,i.e., ampicillin (A), ciprofloxacin (C), gentamicin sulfate(G), erythromycin(E), and polymyxin B sulfate (P), were determined through analyzing the average diameter of the inhibition halos, minimal inhibitory concentration (MIC), fractional inhibitory concentration (FIC) index and the time-killing curves under sub-MIC conditions. The results showed that the antibacterial effect of polyprenols nanoemulsion combined with the antibiotics enhanced with the increase of the average diameter of polyprenols nanoemulsion. The antibacterial effect of polyprenols could be improved by nanoemulsion. The polyprenol combined with gentamicin sulfate had synergistic antibacterial effect against Staphylococcus aureus with the FIC index of 0.5, the diameter of the inhibition halos of (25.8±0.1)mm, and the MIC value of 33.0 mg/L. The time-killing curves showed that the antibacterial effect and the antibacterial time could be increased after polyprenols mixed with gentamicin sulfate.

Key words: Ginkgo biloba, polyprenol, nanoemulsion, antibiotic, antibacterial activity

CLC Number:

TQ35

TAO Ran, WANG Chengzhang, YE Jianzhong, ZHOU Hao, CHEN Hongxia. Antibacterial Activity of Ginkgo biloba Leaves Polyprenols Nanoemulsion in Combination with Antibiotics[J]. Chemistry and Industry of Forest Products, 2017, 37(1): 81-86.

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Antibacterial Activity of Ginkgo biloba Leaves Polyprenols Nanoemulsion in Combination with Antibiotics

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