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Chemistry and Industry of Forest Products ›› 2017, Vol. 37 ›› Issue (1): 81-86.doi: 10.3969/j.issn.0253-2417.2017.01.010

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Antibacterial Activity of Ginkgo biloba Leaves Polyprenols Nanoemulsion in Combination with Antibiotics

TAO Ran1,2, WANG Chengzhang1,2, YE Jianzhong2, ZHOU Hao1,2, CHEN Hongxia2   

  1. 1. Research Institute of Forestry New Technology, CAF, Beijing 100091, China;
    2. Institute of Chemical Industry of Forest Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. of Forest Chemical Engineering, SFA;Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China
  • Received:2016-01-06 Online:2017-02-25 Published:2017-02-25

Abstract: The synergistic antibacterial effects of Ginkgo biloba leaves polyprenols nanoemulsion (GBP) combined with five types of antibiotics,i.e., ampicillin (A), ciprofloxacin (C), gentamicin sulfate(G), erythromycin(E), and polymyxin B sulfate (P), were determined through analyzing the average diameter of the inhibition halos, minimal inhibitory concentration (MIC), fractional inhibitory concentration (FIC) index and the time-killing curves under sub-MIC conditions. The results showed that the antibacterial effect of polyprenols nanoemulsion combined with the antibiotics enhanced with the increase of the average diameter of polyprenols nanoemulsion. The antibacterial effect of polyprenols could be improved by nanoemulsion. The polyprenol combined with gentamicin sulfate had synergistic antibacterial effect against Staphylococcus aureus with the FIC index of 0.5, the diameter of the inhibition halos of (25.8±0.1)mm, and the MIC value of 33.0 mg/L. The time-killing curves showed that the antibacterial effect and the antibacterial time could be increased after polyprenols mixed with gentamicin sulfate.

Key words: Ginkgo biloba, polyprenol, nanoemulsion, antibiotic, antibacterial activity

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