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Chemistry and Industry of Forest Products ›› 2017, Vol. 37 ›› Issue (2): 79-84.doi: 10.3969/j.issn.0253-2417.2017.02.010

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Synthesis and Antibacterial Activity of Bis-alkanoyl-amines Heterocyclic Derivatives of cis-1,8-p-Menthane Diamine

ZHU Shouji1,2, YANG Xuebing3, XU Shichao1,4, ZHAO Zhendong1,4, JIANG Jianxin2   

  1. 1. Institute of Chemical Industry of Forest Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. of Forest Chemical Engineering, SFA;Key Lab.of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China;
    2. College of Material Science and Technology, Bejing Forestry University, Beijing 100083, China;
    3. Sichuan Academy of Forestry, Chengdu 610066, China;
    4. Research Institute of Forestry New Technology, CAF, Beijing 100091, China
  • Received:2016-08-19 Online:2017-04-25 Published:2017-05-04

Abstract: Using dichloroacetonitrile as solvent, Eight bis-alkanoyl-amines heterocyclic derivatives B1-B8 were synthesized through nucleophilic addition-elimination reaction of carboxylic acid chloride containing heterocycle and cis-1, 8-p-menthane diamine. And the yields of derivatives were 53%-100%. The structures of the products were characterized by FT-IR, ESI+-MS, 1H NMR and 13C NMR. The antibacterial activities were determined, and the results showed that some products had excellent antibacterial activities against Staphylococcus aureus and Candida albicans. The minimum inhibitory concentration (MIC) of compound B8 against S. aureus and C. albicans were both 56.25 mg/L.

Key words: cis-1,8-p-menthane diamine, bis-alkanoyl-amines heterocyclic derivatives, synthesis, antibacterial activity

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