Welcome to Chemistry and Industry of Forest Products,

Chemistry and Industry of Forest Products ›› 2020, Vol. 40 ›› Issue (2): 125-130.doi: 10.3969/j.issn.0253-2417.2020.02.017

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The Optimization of Synthesis Process of Nopinone

Yunfei SHI1,Hui ZHANG2,Xuyang ZHONG1,Xinying DUAN1,Shulan CHEN1,Shengliang LIAO1,*()   

  1. 1. College of Forestry, Jiangxi Agricultural University; East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration; Camphor Engineering Research Center of National Forestry and Grassland Administration, Jiangxi Province; Collaborative Innovation Center of Jiangxi Typical Trees Cultivation and Utilization, Nanchang 330045
    2. Jiangxi Forestry Science and Technology Extension Station, Nanchang 330038, China
  • Received:2019-07-29 Online:2020-04-28 Published:2020-04-27
  • Contact: Shengliang LIAO E-mail:alexliao24@163.com


Nopinone is an important forest derivative derived from the oxidation reaction of β-pinene, which is of great significance for further deep processing and utilization of naloxone.In this paper, the optimization for the synthesis process of nopinone from β-pinene was studied.The effects of reaction time, reaction temperature, type and amount of catalyst, n(potassium permanganate):n(β-pinene), type of oxidant, solvent type on reaction conversion and selectivity were discussed.The results showed that when the reaction time was 3 h, the reaction temperature was 21-24℃, the catalyst was cetyltrimethylammonium bromide (CTAB), the amount of catalyst was 0.20 g, the molar ratio of potassium permanganate to β-pinene was 3.2:1, using potassium permanganate as oxidant, acetone as solvent, the conversion rate of the synthesis reaction of nopinone is 99.5%, and the selectivity is 92.2%.

Key words: β-pinene, oxidation, nopinone, phase transfer catalyst

CLC Number: