Welcome to Chemistry and Industry of Forest Products,

›› 2011, Vol. 31 ›› Issue (1): 105-108.

• 研究报告 • Previous Articles     Next Articles

New Synthesis Method of 1,8-Octanediol

KONG Ling-da, ZHENG Zhi-bing   

  1. Institute of Pharmacology and Toxicology, Academy of Miliary Medical Sciences, Beijing 100850, China
  • Received:2010-10-26 Revised:1900-01-01 Online:2011-02-28 Published:2011-02-28

Abstract: A convenient and industrializable new method of synthesizing 1,8-octanediol was studied. 1,8-Octanedioic acid dimethyl ester was obtained at high yield, using hexamethylene dicyanide and methanol as raw material catalyzed by concentrated sulfuric acid, followed by the reduction of 1,8-octanedioic acid dimethyl ester via sodium borohydride in a NaBH4-methanol-tetrahydrofuran solvent system to obtain 1,8-octanediol. Effects of the amount of NaBH4 and reaction time on the overall yield of 1,8-octanediol were investigated. The optimum reaction conditions were as follows: molar ratio of NaBH4 to 1,8-octanedioic acid dimethyl ester 5:5.1, reaction time 8.5h, the yield of 1,8-octanediol was 97.2%.

Key words: 8-octanediol, octanedioic acid dimethyl ester, NaBH4-methanol-tetrahydrofuran system, synthesis

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