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Chemistry and Industry of Forest Products ›› 2016, Vol. 36 ›› Issue (6): 29-34.doi: 10.3969/j.issn.0253-2417.2016.06.005

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Synthesis and Antibacterial Activity of Nitrogenated and Haloid Derivatives of Ginkgo Biloba Leaves Polyprenol

TAO Ran1,2, WANG Cheng-zhang1,2, YE Jian-zhong1, ZHOU Hao1,2, CHEN Hong-xia1   

  1. 1. Institute of Chemical Industry of Forest Products, CAF, National Engineering Lab. for Biomass Chemical Utilization, Key and Open Lab. of Forest Chemical Engineering, SFA, Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China;
    2. Research Institute of Forestry New Technology, CAF, Beijing 100091, China
  • Received:2015-12-31 Online:2016-12-25 Published:2016-12-23

Abstract: Chemical structure modification of -OH in α-terminal unit of Ginkgo biloba leaves polyprenol (GBP) was conducted to prepare five nitrogenated and haloid derivatives of GBP,i.e., polyprenyl phthalimides (GPH), polyprenyl amines (GAM), polyprenyl quaternary ammonium salt (GAS), polyprenyl trifluoroacetate (GTF) and polyprenyl chloroacetate (GCH). All derivatives were identified by 1H NMR. In the study of antibacterial activity, GAS had the highest antibacterial activity against strains Escherichia coli and Staphylococcus aureus with inhibition halos of 19.1-19.8 mm and the minimal inhibitory concentration(MIC) of 31.3 mg/L. At the same time, the time-killing curves of GAS against E.coli and S.aureus under sub-MIC of 15.6 mg/L were drawn and studied. And the results showed that GAS possessed antibacterial activity against E.coli and S.aureus in 48 h and the bacterial number was in a rapid decline within 8 h of exposure in the time-kill studies.

Key words: polyprenol derivatives, synthesis, antibacterial activity, Ginkgo biloba leaves

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