小远志中口山酮类化学成分及生物活性研究

doi:10.3969/j.issn.0253-2417.2017.02.016

Abstract

Abstract: Eighteen compounds were isolated by ethanol extraction, silica gel column chromatography, Sephadex LH-20 column chromatography, MCI-gel column chromatography and semi-preparative HPLC from the dried roots of Polygala sibirica L. var. megalopha Fr. Their structures were identified as 1, 7-dihydroxy xanthone (1), 3, 6-dihydroxy-1, 2, 7, 8-tetramethoxy xanthone (2), 1, 7-dihydroxy-5, 6- dimethoxy xanthone (3), 1, 5-dihydroxy-6, 7-dimethoxy xanthone (4), 6-hydroxy-l, 7-dimethoxy xanthone (5), 7-hydroxy-1-methoxy xanthone (6), 3, 8-dihydroxy- 1, 2, 4-trimethoxy xanthone (7), 6, 8-dihydroxy-1, 2, 3-trimethoxy xanthone (8), 1, 3, 6-trihydroxy-2, 7, 8-trimethoxy- xanthone (9), 3-hydroxy-1, 2, 8-trimethoxy xanthone (10), 1, 3, 7-trihydroxy xanthone (11), 1, 6-dihydroxy-2, 3-methylene-dioxy-7, 8-dimethoxy xanthone (12), 1, 7-dihydroxy-2, 3-dimethoxy xanthone (13), 1, 6-dihydroxy-5, 7-dimethoxy xanthone (14), 3, 7-dihydroxy-1, 2-dimethoxy xanthone (15), 3, 7- dihydroxy- 1, 2, 8-trimethoxy xanthone (16), 1, 2, 3, 7-tetramethoxy xanthone (17), 1, 6-dihydroxy-3, 5, 7, 8-tetramethoxy xanthone (18) by ESI-MS, ¹H NMR, ¹³C NMR. All compounds except 13 were isolated from this plant for the first time. The antioxidant and antimicrobial activities of compound 1-7 were studied. And the results showed that the compound 4(IC₅₀=12 mg/L) and compound 1(IC₅₀=13 mg/L) showed good ABTS scavenging activity and compound 3(MIC=217 μmol/L) had certain inhibitory activity against Staphylococcus aureus.

Key words: Polygala. sibirica L. var. megalopha Fr., xathones, antioxidant, antimicrobial

CLC Number:

TQ35

ZHOU Lingyun, YU Xiaohong, GENG Yuanyuan, HUA Yan. Chemical Constituents and Bioactivities of Xanthones from Polygala sibirica L. var. megalopha Fr.[J]. Chemistry and Industry of Forest Products, 2017, 37(2): 121-128.

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Chemical Constituents and Bioactivities of Xanthones from Polygala sibirica L. var. megalopha Fr.

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