衍生还原裂解法研究木质素类药物的结构

doi:10.3969/j.issn.0253-2417.2013.02.012

›› 2013, Vol. 33 ›› Issue (2): 71-76.doi: 10.3969/j.issn.0253-2417.2013.02.012

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Molecular Structure of Lignin Pharmaceutical Samples by Reductive Cleavage

ZHANG Jing¹, XU Ge¹, YU Da-gang², WU Guo-ping², CHEN He-xin²

1. School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China;2. Jiangsu Jianmin Pharmaceutical Co. Ltd., Changzhou 213018, China

Received:2012-03-26 Revised:1900-01-01 Online:2013-04-30 Published:2013-04-30

Abstract

Abstract: Degradation of lignin pharmaceutical by derivatization followed by reductive cleavage (DFRC) was studied. The compositions and structures of degraded products were analyzed by GC-MS. The results showed that the degraded products from lignin pharmaceutical consisted of four types of compound, i.e., butylated hydroxyltoluene (BHT), monose, organic acid and related lignin units. In 1^# and 2^# pharmaceutical, the content of previous four kinds compounds was 12.696 %, 17.456 %, 17.989 % and 51.859 %; 8.736 %, 2.991 %, 44.812 % and 43.461 %, respectively. According to the biological activity of degraded products obtained by lignin pharmaceutical, the drug actions presumed could be due to the decomposition of lignin pharmaceutical in the human to BHT, ferulic acid and glycerine units. In 1^# and 2^# pharmaceutical, the content of total compounds converted into ferulic acid in the body was 12.572 % and 5.613 %. Furthermore, the content of total containing glycerine units compounds was 6.322 % and 25.430 %, respectively.

Key words: derivatization followed by reductive cleavage, lignin, pharmaceutical, GC-MS

CLC Number:

TQ35
TS721.2

ZHANG Jing;XU Ge;YU Da-gang;WU Guo-ping;CHEN He-xin. Molecular Structure of Lignin Pharmaceutical Samples by Reductive Cleavage[J]. , 2013, 33(2): 71-76.

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Molecular Structure of Lignin Pharmaceutical Samples by Reductive Cleavage

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