%A KUANG Chun-tao KUANG Chun-tao, LI Xiang-zhou, XUE Hai-peng, DENG Nan, WANG Ling-zhi %T Synthesis and Biological Activity of Curcumin Derivatives %0 Journal Article %D 2014 %J Chemistry and Industry of Forest Products %R 10.3969/j.issn.0253-2417.2014.05.011 %P 67-72 %V 34 %N 5 %U {http://www.cifp.ac.cn/CN/abstract/article_1994.shtml} %8 2014-10-28 %X Four curcumin derivatives were synthesized from curucmin and maleic anhydride by esterification, isomerization, chlorination and esterification. The yields of curcumin derivatives c1-c4 were 80.5%, 83.7%, 81.2% and 85.4%, respectively. Their structures were confirmed by IR, 1H NMR and 13C NMR. The antioxidative and antibacterial activities of target compounds c1-c4 were evaluated. The IC50 values for scavenging of DPPH· were 164.14±0.82, 166.98±0.66, 171.97±0.99 and 175.10±2.34 mg/L, respectively. Their antioxidative activity was lower than that of curcumin (36.22±0.22 mg/L). This proved the importance of phenolic OH. The target compounds c1-c4 displayed high antibacterial activity, especially compound c4. The minimal inhibiting concentration(MIC) of c4 against Staphylococcus aureus, Escherichia coli, Penicillium sp. and Aspergillus niger were 0.5, 0.5, 0.25 and 1.0 g/L, respectively. There is hope to obtain antibacterial candidates by curcumin modification with α, β-unsaturated carbonyl compounds.