p-Menth-3-en-1-amine was synthesized from p-menthane diacetylamide by two steps as an acid-catalyzed elimination and an alkaline-catalyzed hydrolysis. The effects of different conditions on these reactions were studied by single-factor and orthogonal tests. The optimal reaction conditions of the acid-catalyzed elimination are shown as 20 mmol p-menthane diacetylamide, 35 mL 12.5% H2SO4 solution (24 mmol) and reaction time 8 h, under which the yield is 41.6%; And the optimized technological parameters of the alkaline-catalyzed hydrolysis are shown as n(N-diacetyl-3-en-1-amine):n(NaOH) 1:7, 30 mL ethylene glycol as the solvent, reaction time 11 h and reaction temperature 170 ℃, to give N-diacetyl-3-en-1-amine in a yield of 82.2%, total yield is 34.2%, purified to 97% by vacuum rectification. The structure of the compound was determined by ESI-MS, FT-IR, 1H NMR and 13C HMR spectroscopic analyses.