Welcome to Chemistry and Industry of Forest Products,

›› 2002, Vol. 22 ›› Issue (04): 80-82.

• 研究简报 • Previous Articles     Next Articles

SYNTHESIS OF 1,3-BENZODIOXOLE-5-ACETIC ACID

ZHOU Ling-jun1, HE Quan-guo2, LIU Zheng-chun2, YANG Chun1, HE Nong-yue2   

  1. 1. College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, China;2. Key Lab for Molecular and Biomolecular Electronics of Ministry of Education, Southeast University, Nanjing 210096, China
  • Received:2002-05-27 Revised:1900-01-01 Online:2002-12-30 Published:2002-12-30

PDF (PC)

1124

Abstract: 1,3-Benzodioxole-5-acetic acid was synthesized from 1,2-benzenediol in a four step procedure.1,2-Benzenediol reacted with dichloromethane to give 1,3-benzodioxole,which was directly chloromethylated to yield 90.1% 5-chloromethyl 1,3-benzodioxole.The chloride was converted easily to 3,4-methlenedioxyphenyl acetonitrile by 80% yield under sodium cyanide nitrilation,followed by alkali hydrolysis to give 1,3-benzodioxole-5-acetic acid.Total yield was 54.2%.Gas chromatography,infrared spectra and elemental analysis were used for characterizations.

Key words: 2-benzenediol, 3-benzodioxole-5-acetic acid

CLC Number: 

Copyright © Institute of Chemical Industry of Forest Products, CAF