Abstract: 8-Hydroxylcarveol(3) and its ester derivatives were synthesized from α-pinene(1), and their structures had been identified by IR, MS, ¹H NMR and ¹³C NMR analysis. The repellent activity against mosquito (Aedes albopictus) of the 4 compounds has been determined by the methods of GB 17322.10-1998. The results are as follows: compound (3) has no repellent against mosquito. On the other hand, it has been reported that compounds having structure simlar to 8-hydroxylcarveol have mosquito-repellent activity, such as p-menthendiol, etc. Perhaps the position of polar functional groups and chiral C atoms are important factors for mosquito-repellent activity. 8-Hydroxylcarveol propionate (6) has no mosquito-repellent activity mosquito, perhaps its carbonyl part is too large. There is few report of propionate used as terpenoid repellent currently. 8-Hydroxylcarveol acetate(5) has some repellent activity against mosquito, when its mass fraction is 20%, which can exhibit repelling time close to 4 h. 8-Hydroxylcarveol formate (4) has the longest repelling time of upto 7-8 h against mosquito, when its mass fraction is 20%, which is similar to the repellent activity of N,N-diethyl-m-toluamide (DETA).

Key words: α-pinene, 8-hydroxylcarveol, ester derivative, Aedes albopictus, mosquito-repellent activity