异海松基水杨酰腙的合成及细胞毒性评价

doi:10.3969/j.issn.0253-2417.2017.04.005

Abstract

Abstract: Isopimaric-based salicylhydrazone was synthesized by the reaction of isopimaric acid (IPA) and salicylaldehyde, and characterized by IR, ¹H NMR and HRMS. The cytotoxicities of target compound were evaluated against two human cancer cells (hepatoma cell HepG-2 and prostatic carcinoma cell PC-3) and a human normal liver cell L-02 in vitro using MTT method, which were compared with that of the positive drug taxol. The results showed that cytotoxic activity of isopimaric-based salicylhydrazone was similar or higher than that of taxol (IC₅₀, 12.14 and 6.48 μmol/L) against HepG-2 and PC-3 cell lines, with IC₅₀ values 6.50 and 9.25 μmol/L, respectively. Moreover, isopimaric-based salicylhydrazone displayed hypotoxicity to L-02 cell, with IC₅₀ value 68.01 μmol/L, which was much lower than that of taxol (IC₅₀, 4.02 μmol/L). The inhibitory rates and cell morphological changes showed that isopimaric-based salicylhydrazone significantly inhibited the cell proliferation in a dose-dependent manner.

Key words: acylhydrazone, isopimaric acid, isopimaric-based salicyloylhydrazone, cytotoxic

CLC Number:

TQ351

LIU Juanjuan, LU Yanju, CHEN Yuxiang, ZHAO Zhendong. Synthesis and Cytotoxicity of Isopimaric-based Salicyloylhydrazone[J]. Chemistry and Industry of Forest Products, 2017, 37(4): 35-39.

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Synthesis and Cytotoxicity of Isopimaric-based Salicyloylhydrazone

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