银杏叶聚戊烯醇金属配合物的合成及其光控活性

doi:10.3969/j.issn.0253-2417.2021.02.010

Abstract

Abstract:

Ginkgo biloba leaves polyprenols(GBP) was used as raw material, and its terminal hydroxyl group was replaced with cyano group by chemical modification method. On this basis, cyano-GBP and ruthenium polypyridine complex were utilized as raw materials, the GBP-ruthenium polypyridine metal complex was synthesized and characterized by complex reaction. The lipid-water partition coefficient, photo-induced ligand dissociation ability and light-controlled antitumor activity of the complex were investigated. NMR results showed that the cyano-GBP and GBP-ruthenium polypyridine metal complex were successfully synthesized. The synthesized complex has good lipid-water partition coefficient(1.35), which was conducive to its penetration of cell membranes. In addition, cyano-GBP ligand of the synthesized complex gradually dissociated under light and exhibited better antitumor activity with the half inhibitory concentration(IC₅₀) against A549 tumor cell of 29.3 μmol/L than GBP(IC₅₀=45.8 μmol/L). Moreover, The light-controlled antitumor activity of the complex may be related to its DNA binding ability.

Key words: Ginkgo biloba leaves, polyprenols, ruthenium polypyridine, metal complex, light-controlled activity

CLC Number:

TQ35

Changwei ZHANG, Ran TAO, Zhiwen QI, Hong SHEN, Xingying XUE, Chengzhang WANG. Synthesis and Light-controlled Activity of Ginkgo biloba Leaves Polyprenols Metal Complex[J]. Chemistry and Industry of Forest Products, 2021, 41(2): 73-78.

Figures/Tables 7

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Synthesis and Light-controlled Activity of Ginkgo biloba Leaves Polyprenols Metal Complex

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