β-蒎烯合成抗糖尿病药物那格列奈

›› 2007, Vol. 27 ›› Issue (04): 92-96.

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Synthesis of Nateglinide as an Antidiabetic Drug from β-Pinene

MA Shi-ying^1,2, SHEN Min-min¹, HA Cheng-yong¹, GAO Hong-yun^1,2

1. Key Laboratory of Cellulose and Lignocellulosics Chemistry, Chinese Academy of Sciences, Guangzhou 510650, China;2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China

Received:2006-05-29 Revised:1900-01-01 Online:2007-08-30 Published:2007-08-30

Abstract

Abstract: Starting from β-pinene, nateglinide was synthesized through oxidation, acid-catalytic rearran-gement, hydrogenization, isomerization and acylation. The chemical structure of the target compound is confirmed by IR, ¹H NMR, ¹³C NMR, MS. Nateglinide was successfully synthesized by using natural product as starting material,via six steps in a total yield of 28.1% with the advantages of simple operation and low cost.

Key words: β-pinene, nateglinide, trans-4-isopropyl cyclohexanecarboxylic acid

CLC Number:

TQ351.472

MA Shi-ying;SHEN Min-min;HA Cheng-yong;GAO Hong-yun;. Synthesis of Nateglinide as an Antidiabetic Drug from β-Pinene[J]. , 2007, 27(04): 92-96.

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Synthesis of Nateglinide as an Antidiabetic Drug from β-Pinene

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