›› 2011, Vol. 31 ›› Issue (1): 86-90.
• 研究报告 • Previous Articles Next Articles
JIANG Ping, LI Hai-yu, MI Wei
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Abstract: Epoxidation of anethole with H2O2 could have 91% yield of 2-(4-methoxyphenyl)-3-methyloxirane. The effects of the ratio of CH3CN/CH3OH, molar ratio of anethole and H2O2 , dosage of catalyst, reaction temperature and reaction time on the yield were investigated. The results showed that the volume of CH3CN/CH3OH was 1:5, the molar ratio of anethole and H2O2 was 1:2.5, the molar ratio of anethole and anhydrous sodium carbonate was 1:0.8, reaction temperature was room temperature and reaction time was 27h. Then, reduction of 2-(4-methoxyphenyl)-3-methyloxirane with lithium aluminum hydride was used to obtain 1-(4-methoxyphenyl)-2-propanol. By single factor experiment, the results showed that the optimized conditions were as follows: ether as the best solvent, molar ratio of raw material to reducing agent was 1:1.5, reaction temperature at room temperature and reaction time 1h. The structures of the two compounds were characterized by GC-MS and IR.
Key words: anethole, 2-(4-methoxyphenyl)-3-methyloxirane, 1-(4-methoxyphenyl)-2-propanol, lithium aluminum hydride
CLC Number:
TQ3510
JIANG Ping;LI Hai-yu;MI Wei. Study on Synthesis of Anethole Derivatives[J]. , 2011, 31(1): 86-90.
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