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林产化学与工业

林产化学与工业 ›› 2004, Vol. 24 ›› Issue (2): 73-76.

• 研究报告 • 上一篇    下一篇

超临界反溶剂过程制备槲皮素超细颗粒

刘学武, 李志义, 韩冰, 夏远景, 苑塔亮   

  1. 大连理工大学 流体与粉体工程研究设计所, 辽宁 大连 116012
  • 收稿日期:2003-11-13 修回日期:1900-01-01 出版日期:2004-06-30 发布日期:2004-06-30

PREPARATION OF MICROPARTICLE OF QUERCETIN BY SUPERCRITICAL ANTI-SOLVENT PROCESS

LIU Xue-wu, LI Zhi-yi, HAN Bing, XIA Yuan-jing, YUAN Ta-liang   

  1. Research and Design Institute of Fluid and Powder, Dalian University of Technology, Dalian 116012, China
  • Received:2003-11-13 Revised:1900-01-01 Online:2004-06-30 Published:2004-06-30

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摘要： 超临界反溶剂过程是近年来提出的一种制备纳微米粉体材料的新方法。本研究建立了一套连续的超临界反溶剂过程实验装置,以槲皮素、乙醇及二氧化碳系统为研究对象,实验研究了不同压力、温度和二氧化碳与溶液流率比对结晶颗粒形状与尺寸的影响。实验结果表明:采用乙醇作为有机溶剂可制备出平均直径在1～6μm范围内的槲皮素超细颗粒;且操作压力对实验结果的影响最大,温度次之,体积流率比影响最小。

关键词: 超临界反溶剂过程, 超细颗粒, 槲皮素

Abstract: Supercritical anti-solvent(SAS) process is a recently developed technology to produce micro- and nano-particles.This paper presents a continuous apparatus to conduct SAS process experiments.With the apparatus,the effects of pressure,temperature and flow ratio of CO2 to the solution on the shape and size of the particles are studied in a quercetin-ethanol-CO2 system.The experimental results show that spherical quercetin microparticles with diameters ranging 1-6 μm can be obtained by SAS process when ethanol is used as organic solvent.The most effective parameter on the shape and size of the particles is pressure,followed by temperature and the last is flow ratio of CO2 to solution.

Key words: supercritical anti-solvent process, micro-particles, quercetin

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