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林产化学与工业

林产化学与工业 ›› 2012, Vol. 32 ›› Issue (5): 1-6.

• 1研究报告 •    下一篇

脱氢枞胺及其Schiff碱衍生物与DNA作用的研究

费宝丽1,2, 李雯1, 张典1, 夏兵3, 龙剑英3, 刘庆波3   

  1. 1. 南京林业大学 化学工程学院, 江苏 南京 210037;2. 南京大学 配位化学国家重点实验室, 江苏 南京 210093;3. 南京林业大学 理学院, 江苏 南京 210037
  • 收稿日期:2011-12-23 修回日期:1900-01-01 出版日期:2012-10-30 发布日期:2012-10-30

DNA-Binding Studies of Dehydroabietylamine and Its Schiff Base Derivatives

FEI Bao-li1,2, LI Wen1, ZHANG Dian1, XIA Bing3, LONG Jian-ying3, LIU Qing-bo3   

  1. 1. College of Chemical Engineering,Nanjing Forestry University, Nanjing 210037, China;2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China;3. College of Science,Nanjing Forestry University, Nanjing 210037, China
  • Received:2011-12-23 Revised:1900-01-01 Online:2012-10-30 Published:2012-10-30

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摘要： 合成了N-(2-亚甲基吡啶)脱氢枞胺Schiff碱(L2)及其还原产物(L3),利用元素分析、红外、核磁、质谱进行了表征。通过紫外吸收光谱、荧光光谱、圆二色谱和黏度分析的方法研究了脱氢枞胺、Schiff碱及还原Schiff碱与鲑鱼精DNA的作用,结果表明3个化合物均以插入的模式与DNA作用,且Schiff碱与DNA的结合能力最强。

关键词: 脱氢枞胺, Schiff碱, DNA作用

Abstract: N-[(pyridin-2-ylmethylene)-imino]dehydroabietylamine schiff base (L2) and its reduced form (L3) were synthesized and characterized by elemental analysis, IR spectra, 1H NMR and MS techniques. The interaction between individual compound and salmon sperm DNA was investigated by UV, fluorescence and circular dichroism (CD) spectroscopic and viscosity analysis. Results show that all the three compounds bind to DNA by intercalation mode, and the schiff base is the strongest binding agent among them.

Key words: dehydroabietylamine, schiff base, DNA interaction

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