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林产化学与工业

林产化学与工业 ›› 2009, Vol. 29 ›› Issue (6): 38-42.

• 研究报告 • 上一篇    下一篇

杨树芽提取物体外抗肿瘤活性的研究

郑光耀1, 康宏兴2, 薄采颖1, 宋强1, 周维纯1   

  1. 1. 中国林业科学研究院, 林产化学工业研究所, 生物质化学利用国家工程实验室, 国家林业局林产化学工程重点开放性实验室, 江苏 南京 210042;2. 南京老山林场, 江苏 南京 211811
  • 收稿日期:2009-08-05 修回日期:1900-01-01 出版日期:2009-12-30 发布日期:2009-12-30

Study on Anti-tumor Activity of Poplar Bud Extract in vitro

ZHENG Guang-yao1, KANG Hong-xing2, BO Cai-ying1, SONG Qiang1, ZHOU Wei-chun1   

  1. 1. Institute of Chemistry and Industry of Forest Products, CAF;National Engineering Lab.for Biomass Chemical Utilization;Key and Open Lab.on Forest Chemical Engineering, SFA, Nanjing 210042, China;2. Nanjing Laoshan Forest Farm, Nanjing 211811, China
  • Received:2009-08-05 Revised:1900-01-01 Online:2009-12-30 Published:2009-12-30

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摘要： 采用四甲基偶氮唑盐比色(MTT)法观察杨树芽提取物对MCF-7、SMMC-7721和A5493种肿瘤细胞的体外生长抑制作用,并与市售蜂胶和杨树胶的抗肿瘤活性进行对比。结果表明:杨树芽提取物对3种肿瘤细胞作用 48 h 的抑制率分别为 97.1%、88.7% 和 60.5%,半数抑制质量浓度(IC50)分别为58.4、83.9和 196.3 mg/L,均高于蜂胶和杨树胶。杨树芽提取物对体外培养的肿瘤细胞生长有明显的抑制作用,提示杨树芽提取物具有良好的抗肿瘤活性。

关键词: 杨树芽提取物, 四甲基偶氮唑盐比色法, 抗肿瘤活性

Abstract: The growth-inhibition effect of poplar bud extract on MCF-7, SMMC-7721 and A549 cell lines by MTT assay were observed and the anti-tumor activity was compared with propolis and poplar gum from market. The results showed that the inhibitory rates of poplar bud extract on the three cell lines for 48 h, were 97.1%, 88.7% and 60.5%, with the IC50 of 58.4, 83.9 and 196.3 mg/L, respectively, which were higher than those of propolis and poplar gum. Poplar bud extract has significantly inhibited the growth in vitro on the three cell lines, suggesting that poplar bud extract has obvious anti-tumor activity.

Key words: poplar bud extract, MTT assay, anti-tumor activity

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