2,3,4-三甲氧基苯甲酸的合成研究

›› 2008, Vol. 28 ›› Issue (3): 91-93.

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Study on Synthesis of 2,3,4-Trimethoxybenzoic Acid

XU Hao¹, HUANG Jia-ling², QIN Qing¹, WANG Guang-hui¹, TAO Lin²

1. Institute of Chemical Industry of Forest Products, CAF; Key and Open Lab.on Forest Chemical Engineering, SFA, Nanjing 210042, China;2. Nanjing Longyuan Natural Polyphenol Synthesis Factory, Nanjing 210032, China

Received:2008-01-17 Revised:1900-01-01 Online:2008-06-30 Published:2008-06-30

Abstract

Abstract: Preparation method of 2,3,4-trimethoxybenzoic acid is introduced, which was synthesized from 2,3,4-trihydroxybenzoic acid by methylation,hydrolysis,acidification and purification. The results showed that the optimal methylating condition was as follows: dosage ratio of dimethyl sulfate to 2,3,4-trihydroxybenzoic acid 4:1,dosage of calalyst 5%of 2,3,4-trihydroxybenzoic acid. The structure of the refined product was confirmed by IR and ¹H NMR.The purity was 99.54% by HPLC.

Key words: 4-trimethoxybenzoic acid, 4-trihydroxybenzoic acid

CLC Number:

TQ91

XU Hao;HUANG Jia-ling;QIN Qing;WANG Guang-hui;TAO Lin. Study on Synthesis of 2,3,4-Trimethoxybenzoic Acid[J]. , 2008, 28(3): 91-93.

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Study on Synthesis of 2,3,4-Trimethoxybenzoic Acid

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