Abstract: A new environmental friendly catalyst, TiSiW₁₂O₄₀/TiO₂ was prepared and characterized by IR and XRD.Synthesis of fraistone with ethyl acetoacetate and 1, 2 propylene glycol as reactants and TiSiW₁₂O₄₀/TiO₂ as catalyst was studied.Results showed that TiSiW₁₂O₄₀/TiO₂ was an excellent catalyst for the synthesis of fraistone, and the optimum reaction conditions was as follows:molar ratio of ethyl acetoacetate to 1, 2 propylene glycol 1:1.5, dosage of catalyst 1.0% of feed stock, reaction time 1.0 h.under this condition, yield of fraistone was about 83.3%.The catalyst can be reused for at least six times.

Key words: fraistone, TiSiW₁₂O₄₀/TiO₂