低共熔溶剂在分子印迹技术中的应用研究进展

doi:10.3969/j.issn.0253-2417.2022.06.017

Abstract

Abstract:

Using the roles of deep eutectic solvents(DES) in the molecularly imprinted polymers(MIP) as the main line, the roles of different components of DES in the preparation process of MIP were summarized. DES was used as the template molecule to enhance its water solubility, and make the synthesized MIP with good selectivity. DES could be used as the functional monomer or auxiliary functional monomer to increase the binding site with template molecules and effectively improve the affinity of the target. As the pore-forming agent, DES could reduce environmental pollution and improve pore permeability. DES was used as eluent to realize the advantages of environmental friendliness and low cost separation. DES could also modify the support of imprinted molecules on the surface, so that the required functional groups could be obtained after the support surface was loaded with DES, which was conducive to the preparation of molecule-imprinted polymers and could improve the adsorption performance of molecule-imprinted polymers. Meanwhile, a theoretical basis and development direction for the application of DES in the future green separation of molecular imprinting technology(MIT) was prospected.

Key words: deep eutectic solvent(DES), molecular imprinting technology(MIT), green chemistry, separation of natural products

CLC Number:

TQ35

Chunhui MA, Xiaojing WANG, Lihan SUN, Wei LI, Sha LUO, Shouxin LIU. Application of Deep Eutectic Solvents in Molecular Imprinting Separation Technology[J]. Chemistry and Industry of Forest Products, 2022, 42(6): 123-135.

Figures/Tables 7

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功能单体(n∶n)¹⁾ functional monomer	模板分子 template molecule	MIP性能参数²⁾ molecularly imprinted polymers	文献 ref.
ChCl/AA(1∶2)	转铁蛋白transferrin(TrF)	IF 3.50	[45]
3-ATLC/U(1∶2)	牛血红蛋白bovine hemoglobin(BHb)	IF 4.93	[46]
ChCl/OA/1, 2-PG(1∶1∶2)	黄芩苷baicalin	Q 7.06 mg/g	[47]
VP/MA(1∶1)	儿茶素catechins	IF 9.23	[48]
CA/ChCl/FA(1∶6∶3)	槲皮素quercetin, 五味子乙素schisandrin B	Q_q23.58 mg/g, Q_s41.64 mg/g	[49]
CA/ChCl/EG(1∶5∶5)	黄酮类化合物flavonoids	Y_q96.8%, Y_i93.6%, Y_k94.8%	[50]

DES组成(n∶n)¹⁾ composition of DES	功能单体 functional monomer	目标产物 target product	产物回收率/% recovery rate of product	文献 ref.
ChCl/GL(1∶2)	丙烯酰胺 acrylamide(AM)	绿原酸chlorogenic acid	72.56	^[51]
ChCl/U(1∶2)	甲基丙烯酸 methacrylic acid(MAA)	丹参酮Ⅰ tanshinone Ⅰ 丹参酮ⅡA tanshinone ⅡA 隐丹参酮cryptotanshinone	85.57 80.58 92.12	^[52]
		大豆素glycitein 染料木素genistein 甘油素daidzein	92.24 87.72 81.65
		表儿茶素epicatechin 表没食子儿茶素没食子酸酯epigallocatechin gallate 表儿茶素没食子酸酯epicatechin gallate	86.43 80.92 93.64
ChCl/GL(1∶2)	AM	氯霉素chloromycetin 甲砜霉素thiamphenicol	91.23 87.02	^[53]
ChCl/GL(1∶3)	MAA	芦丁rutin 东莨菪酮scoparone 槲皮素quercetin	92.27 87.51 80.02	^[54]

[1]	XIE Yitong, GUO Xin, Lü Yanna, WANG Haisong. Research Progress on the Dissolution of Lignocellulose and Separation of Its Components by Deep Eutectic Solvents [J]. Chemistry and Industry of Forest Products, 2019, 39(5): 11-18.
[2]	SHEN Shao-chuan;YAO Ke-jian. GREEN CHEMISTRY & GREEN SEPARATION ENGINEERING [J]. , 2001, 21(3): 83-86.

Application of Deep Eutectic Solvents in Molecular Imprinting Separation Technology

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