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林产化学与工业

林产化学与工业 ›› 2014, Vol. 34 ›› Issue (1): 19-24.doi: 10.3969/j.issn.0253-2417.2014.01.004

• 研究报告 • 上一篇    下一篇

磁性聚N-异丙基丙烯酰胺-聚丙烯酸纳米复合微球的制备与性能研究

南静娅1, 陈莹1,2, 王春鹏1,2, 储富祥3   

  1. 1. 中国林业科学研究院 林产化学工业研究所; 生物质化学利用国家工程实验室; 国家林业局 林产 化学工程重点开放性实验室; 江苏省 生物质能源与材料重点实验室, 江苏 南京 210042;
    2. 中国 林业科学研究院 林业新技术研究所, 北京 100091;
    3. 中国林业科学研究院, 北京 100091
  • 收稿日期:2013-01-05 出版日期:2014-02-25 发布日期:2014-03-05
  • 通讯作者: 陈莹，副研究员，主要从事天然高分子纳米微粒的合成、表征和性能研究；E-mail：yingchencaf@gmail.com。 E-mail:yingchencaf@gmail.com
  • 作者简介:南静娅（1988-），女，山西运城人，硕士生，主要从事高分子复合微球方面的研究工作
  • 基金资助:
    国家国际科技合作专项项目（2011DFA32440）；国家自然科学基金资助项目（31100427）；中国林科院林业新技术所基本科研业务费专项资金（CAFINT 2010C06）

Preparation and Characterization of Magnetic Poly (N-isopr-opylacrylamide)-poly (Acrylic Acid) Hybrid Nanospheres

NAN Jing-ya1, CHEN Ying1,2, WANG Chun-peng1,2, CHU Fu-xiang3   

  1. 1. Institute of Chemical Industry of Forest Products, CAF; National Engineering Lab.for Biomass Chemical Utilization; Key and Open Lab.of Forest Chemical Engineering, SFA; Key Lab.of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China;
    2. Institute of New Technology of Forestry, CAF, Beijing 100091, China;
    3. Chinese Academy of Forestry, Beijing 100091, China
  • Received:2013-01-05 Online:2014-02-25 Published:2014-03-05

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摘要： 以天然高分子羟丙基纤维素-聚丙烯酸（HPC-PAA）胶体微粒为模板，通过沉淀聚合法获得中空结构的聚N-异丙基丙烯酰胺-聚丙烯酸（PNIPAm-PAA）纳米胶囊，平均粒径约为 500 nm；然后运用静电作用自组装法和原位还原法将Fe3O4磁性纳米粒子负载于PNIPAm-PAA纳米胶囊上，制备获得Fe3O4/PNIPAm-PAA磁性纳米复合微球，粒径约为 400 nm。制得的复合微球不仅具有一定的铁磁性（饱和磁化强度为5.5（A·m2）/kg，而且对抗肿瘤药物——盐酸阿霉素（Dox）显示了较高的载药率和较好的体外缓释效果，有望成为一种新型的靶向药物载体应用于药物输送体系。

关键词: 聚N-异丙基丙烯酰胺, 聚丙烯酸, 纳米胶囊, 磁性复合微球, 靶向药物载体

Abstract: In this study, a convenient approach has been proposed for the preparation of magnetic poly (N-isopropylacrylamide)-poly (acrylic acid) (PNIPAm-PAA) hybrid nanospheres. In the first step, hollow PNIPAm-PAA nanocapules, of which the diameter was about 500 nm, were synthesized by precipitation polymerization with hydropropylcellulose-poly (acrylic acid) (HPC-PAA) particles as the template. In the second step, the electrostatic interaction self-assembly method and the in situ reduction method were adopted to generate the magnetic Fe3O4 nanoparticles inside the nanocpsules. Thus the magnetic Fe3O4/PNIPAm-PAA hybrid nanospheres were finally obtained and the average diameter was 400 nm. In addition, a high drug loading capacity and a sustained-release behavior were presented by using anti-cancer drug Doxorubicin hydrochloride (Dox) as a hydrophilic model drug. It indicated that the Fe3O4/PNIPAm-PAA hybrid nanospheres might be used as a new magnetic-targeted drug carrier for the drug delivery system.

Key words: poly (N-isopropylacrylamide), poly (acrylic acid), nanocapules, magnetic hybrid nanospheres, targeted drug carrier

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