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林产化学与工业

林产化学与工业 ›› 2007, Vol. 27 ›› Issue (6): 81-84.

• 研究报告 • 上一篇    下一篇

磺化去氢枞酸盐的合成与生物活性测试

韩春蕊1, 宋湛谦1, 李海涛2, 杨冬梅2   

  1. 1. 中国林业科学研究院 林产化学工业研究所;国家林业局 林产化学工程重点开放性实验室, 江苏 南京 210042;2. 南京中医药大学 药学院, 江苏 南京 210029
  • 收稿日期:2006-12-19 修回日期:1900-01-01 出版日期:2007-12-30 发布日期:2007-12-30
  • 通讯作者: 宋湛谦,中国工程院院士,研究员,博士生导师,从事生物质资源的化学改性和应用,特别是松脂资源的深加工利用研究;E-mail:zqsong@public1.ptt.js.cn。

Synthesis and Bioactivity of Sulfodehydroabietates

HAN Chun-rui1, SONG Zhan-qian1, LI Hai-tao2, YANG Dong-mei2   

  1. 1. Institute of Chemical Industry of Forest Products, CAF;Key and Open Lab. on Forest Chemical Engineering, SFA, Nanjing 210042, China;2. Pharmaceutical Institute, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China
  • Received:2006-12-19 Revised:1900-01-01 Online:2007-12-30 Published:2007-12-30

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摘要： 以去氢枞酸为原料,经过磺化得到磺化去氢枞酸,再与金属盐直接反应合成出多种磺化去氢枞酸盐;用IR对产物进行了表征;研究了金属盐直接反应法制备不同磺化去氢枞酸盐的反应体系的最佳pH值;确定了用于抗胃酸活性的磺化去氢枞酸盐的种类.对磺化去氢枞酸亚铁盐进行了毒理学和病理学测试,测试结果显示该亚铁盐基本无毒,用药量分别为50、100、200mg/kg时,胃酸量和总胃酸抑制率效果均比阳性药西咪替丁用药量为160mg/kg时好.

关键词: 磺化去氢枞酸, 亚铁松香酸盐, 抗胃酸, 西咪替丁

Abstract: Several sulfodehydroabietates were prepared via sulphonation and salt reaction using dehydroabietic acid directly as raw material. The structures were characterized by IR. One-step salt reaction was studied in detail, especially the effect of pH value of system, which is the critical factor. The optimum pH values of different systems were obtained by simulating reaction and comparing to theoretical pH value of generating precipitation. According to body pH value and toxicity, ferrous iron, cobalt, nickel and manganese salts were selected for synthesizing sulfodehydroabietates, which are resistant to gastric juice activity. The pathology and toxicology of dis-ferrous sulfodehydroabietate were studied. The results showed that the toxicology is very low, the inhibition to gastric secretion and inhibition ratio of total acid by ferrous sulfodehydroabietate at 50, 100, 150 mg/kg doses respectively are better than that of cimitidine at 160 mg/kg dose.

Key words: sulfodehydroabietic acid, ferrous sylvate, gastric juice resistance, cimitidine

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