马尾松树皮提取物抗脑缺血和抗脑肿瘤作用的研究

林产化学与工业 ›› 2007, Vol. 27 ›› Issue (S1): 21-23.

马尾松树皮提取物抗脑缺血和抗脑肿瘤作用的研究

郑光耀¹, 王成章¹, 谢衡², 李若达², 陈文英¹, 陈虹霞¹

1. 中国林业科学研究院林产化学工业研究所;国家林业局林产化学工程重点开放性实验室, 江苏南京 210042;2. 广东嵩珍营养源研究所, 广东乐昌 512229

收稿日期:2007-06-20 修回日期:1900-01-01 出版日期:2007-10-20 发布日期:2007-10-20

Protective Effects of Masson's Pine Bark Extract on Incomplete Cerebral Ischemia of Mice and Brain Tumor of Nude Mice

ZHENG Guang-yao¹, WANG Cheng-zhang¹, XIE Heng², LI Ruo-da², CHEN Wen-ying¹, CHEN Hong-xia¹

1. Institute of Chemical Industry of Forest Products, CAF;Key and Open Lab. on Forest Chemical Engineering, SFA, Nanjing 210042, China;2. Institute of Songzhen Nutritional Resource, Lechang 512229, China

Received:2007-06-20 Revised:1900-01-01 Online:2007-10-20 Published:2007-10-20

摘要/Abstract

摘要： 研究马尾松树皮提取物(MPBE)抗脑缺血和抗脑肿瘤的作用.采用结扎小鼠双侧带迷走神经的颈总动脉造成急性不完全脑缺血模型,测定小鼠的存活时间,采用裸小鼠移植人脑瘤(SF763)的脑内接种模型,测定裸小鼠的生命延长率.结果表明:MPBE可明显延长急性不完全脑缺血小鼠的存活时间,MPBE与阿霉素(ADM)联合使用可明显延长脑瘤裸小鼠的生命延长率,MPBE具有一定的抗脑缺血和抗脑肿瘤的作用.

关键词: 马尾松树皮提取物, 脑缺血, 脑肿瘤

Abstract: To investigate the protective effects of masson's pine bark extract (MPBE) on incomplete cerebral ischemia of mice and brain tumor of nude mice,the model of acute incomplete cerebral ischemia in mice was established by ligating bilateral carotid arteries, and the model of intrabrain transplanted tumor in nude mice was established by implanting human brain tumor (SF763). The survival time was observed in these two models, respectively. Results showed: the survival time of mice by bilateral carotid arteries ligation was obviously prolonged with the dose of MPBE. The rate of life prolongation of nude mice by human brain tumor implantion was obviously increased with the dose of MPBE combining with ADM. MPBE may be useful for prevention of cerebral ischemia and brain tumor.

Key words: masson's pine bark extract, cerebral ischemia, brain tumor

中图分类号:

TQ91

郑光耀;王成章;谢衡;李若达;陈文英;陈虹霞. 马尾松树皮提取物抗脑缺血和抗脑肿瘤作用的研究[J]. 林产化学与工业, 2007, 27(S1): 21-23.

ZHENG Guang-yao;WANG Cheng-zhang;XIE Heng;LI Ruo-da;CHEN Wen-ying;CHEN Hong-xia. Protective Effects of Masson's Pine Bark Extract on Incomplete Cerebral Ischemia of Mice and Brain Tumor of Nude Mice[J]. , 2007, 27(S1): 21-23.