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林产化学与工业

林产化学与工业 ›› 2009, Vol. 29 ›› Issue (4): 11-16.

• 研究报告 • 上一篇    下一篇

超临界二氧化碳去除苦参中脂溶性物质的研究

杜爱玲1, 胡晶红2, 杜爱琴1, 张艳霞3, 贾燕高1   

  1. 1. 山东大学 化学与化工学院, 山东 济南 250061;2. 山东中医药大学 药学院, 山东 济南 250355;3. 泰山学院 材料与化学工程系, 山东 泰安 271021
  • 收稿日期:2008-09-17 修回日期:1900-01-01 出版日期:2009-08-30 发布日期:2009-08-30
  • 通讯作者: 杜爱琴(1964- ),女,山东海阳人,高级实验师,从事分析化学领域的研究;E-mail:duaiqin66@163.com。

Removal of Lipid-soluble Substances from Sophora flavescens Ait. by Supercritical Carbon Dioxide Prior to the Extraction of Matrine-type Alkaloids

DU Ai-ling1, HU Jing-hong2, DU Ai-qin1, ZHANG Yan-xia3, JIA Yan-gao1   

  1. 1. School of Chemistry and Chemical Engineering, Shandong University, Ji'nan 250061, China;2. Pharmaceutical Schoool, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China;3. Departmant of Materials and Chemical Engineering, Taishan Institute, Taian 271021, China
  • Received:2008-09-17 Revised:1900-01-01 Online:2009-08-30 Published:2009-08-30

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摘要： 苦参是一种用于治疗多种疾病的传统中药材,苦参碱类生物碱是其主要的活性物质,既有药用价值又有杀虫效果。作者利用超临界二氧化碳(SC-CO2)去除苦参中的脂溶性物质,建立了节能环保的后续苦参碱提取工艺。检测了脂溶性物质(R1)和苦参总碱(R2)的得率;评价了超临界流体萃取(SFE)过程的参数,如压力、温度、时间对R1和R2的影响,并与直接溶剂萃取进行对照。结果显示,使用本法所得苦参总碱的平均产率比直接用溶剂萃取高 72%,在压力为12～18 MPa、温度60～75℃、萃取时间 2h 下苦参碱得率较高。

关键词: 超临界流体萃取, 苦参碱, 脂溶性物质

Abstract: Sophora flavescens Ait. is a traditional Chinese medicine thathas been used for the treatment of various diseases for centuries. Matrine-type alkaloids are the primary active substances that can be used in medicine and pesticide. In this paper, supercritical carbon dioxide (SC-CO2) was used to remove lipid-soluble substances so that a cleaner sample of S.flavescens was available for extraction of matrine-type alkaloids. The recovery of lipid-soluble substances (R1) and the recovery of matrine-type alkaloids (R2) were investigated. Parameters of supercritical fluid extraction (SFE), such as pressure, temperature, time and their effects were evaluated. Furthermore, a comparison between this method and the direct solvent extraction method was made, and an average of 72%higher yield of matrine-type alkaloids was obtained by the former method. Thehigh yield of matrine-type alkaloids was obtained at pressure 12-18 MPa, temperature 60-75℃ for 2h.

Key words: supercritical fluid extraction, matrine-type alkaloids, lipid-soluble substances

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