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林产化学与工业

林产化学与工业 ›› 2004, Vol. 24 ›› Issue (S1): 123-125.

• 研究报告 • 上一篇    下一篇

微晶纤维素与抗菌剂复合体解吸条件及其释放量

王福祥1, 恩·柯捷里尼可娃2, 侯永发1, 恩·鲁吉娜2   

  1. 1. 中国林业科学研究院 林产化学工业研究所, 江苏 南京 210042;2. 俄罗斯科学院 高分子化合物研究所, 俄罗斯 圣彼德堡 197198
  • 收稿日期:2003-05-09 修回日期:1900-01-01 出版日期:2004-10-20 发布日期:2004-10-20

DESORPTION CONDITION AND DESORPTION AMOUNT OF MICROCRYSTALLINE CELLULOSE(MCC)-ANTIBIOTIC COMPLEX

WANG Fu-xiang1, KOTELNIKOVA N E2, HOU Yong-fa1, ZAIKINA N D2   

  1. 1. Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, China;2. The institute of Macromolecule Compounds of Russian Academy, St.Petersburg 197198, Russia
  • Received:2003-05-09 Revised:1900-01-01 Online:2004-10-20 Published:2004-10-20

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摘要： 实验表明,微晶纤维素(MCC)对卡达波尔(抗菌剂)的吸附量与卡达波尔原始浓度C0有关,即C0越高,吸附量越大。木浆MCC吸附量高于其它种类。另外,模拟人体肠胃(消化)系统生理过程条件,研究了不同种类MCC-卡达波尔复合体解吸状况。结果表明,在pH值2.0(相当于人体胃内条件)时,解吸程度最大(63.1%～73.7%);在pH值9.0(相当于人体肠内条件)时,尚能继续补充解吸。两段解吸总量达70%～90%。证明该复合体可以作为胃肠药剂,用于实践发挥疗效。

关键词: 微晶纤维素, 抗菌剂, 复合药物

Abstract: Result of experiment shows: the adsorption amount of microcrystalline cellulose MCC for catapol antibiotic is related with catapol’s original concentrationC0. The higher C0 is, the more adsorption of MCC is. The adsorption amount of wood pulp MCC is higher than others. By imitating the physiological condition of human stomach intestine system digestive system, we studied the adsorption and desorption of different kinds of the complex MCC-catapol. The result shows that at pH value 2.0 equivalent to the condition in the stomach of human body, the desorption level arrived the max (63.1% -73.7%); at pH value 9.0 equivalent to the condition in the intestines of human body, the complex which desorbed at pH value 2.0 can still desorb continuously. Total desorption amounts of these two stages reach 70%-90%, which proved that the complex could be used as stomach-intestines medicament.

Key words: microcrystalline cellulose(MCC), antibiotic, compound medicine

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