cellulose-g-PMMA的合成及其胶束作为药物载体的研究

doi:10.3969/j.issn.0253-2417.2015.01.004

Abstract

Abstract: Cellulose chloracetate, as a macromolecular initiator, was prepared by using cellulose as raw material, and ionic liquid as the reaction medium. Then, it was used for atom transfer radical polymerization to prepare cellulose-g-polymethyl methacrylate (cellulose-g-PMMA) using methyl methacrylate (MMA) as monomer and cellulose ester/CuBr/2,2-bipyridyl as the initiator system. The cellulose-g-PMMA was characterized by FT-IR, XRD, TGA and so on. The crystalline degree of cellulose is 57.9%, and fall to 38.39% by chemical modification. In the selective solvent acetone, the average particle diameter of the product was about 40-70 nm. TEM images showed that the copolymer micelles was spherical shape and the particle size was about 200 nm with core-shell structure. Aspirin was used as a model drug loading in the copolymer micelles to investigate the influence of the degree of cellulose modification on drug release efficiency. Drug release time of the cellulose-g-PMMA obtained by grafted polymerization for 3 h had 88.9% drug release rate after 72 h at 37℃. This cellulose-g-PMMA exhibited a good effect on drug release.

Key words: cellulose, ionic liquid, atom transfer radical polymerization (ATRP), drug carrier

CLC Number:

TQ35

ZHONG Li-li, GAO Yuan, ZHANG Li-ping. Synthesis of Cellulose-g-PMMA and Its Micelles Using as Drug Carriers[J]. Chemistry and Industry of Forest Products, 2015, 35(1): 23-29.

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Synthesis of Cellulose-g-PMMA and Its Micelles Using as Drug Carriers

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