Welcome to Chemistry and Industry of Forest Products,

›› 2003, Vol. 23 ›› Issue (2): 73-76.

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CHEMICAL CONSTITUENTS FROM LEAVES OF CALOPHYLLUM MEMBRANACEUM GARDN.

CHEN Guang ying1,2, HAN Chang ri1, SONG Xiao ping1, HUANG Hua rong2, LIN Yong cheng2   

  1. 1. Department of Chemistry, Hainan Normal University, Haikou 571158, China;2. Department of Chemistry, Zhongshan University, Guangzhou 510275, China
  • Received:2002-09-30 Revised:1900-01-01 Online:2003-06-30 Published:2003-06-30

Abstract: Six compounds, namely:friedelin(1), β-sitosterol(2), canophyllol(3), isocalophyllic acid(4), amentoflavone(5) and canophyllic acid(6) were isolated from the leaves of Calophyllum membranaceum Gardn.et Champ.Their structures were determined by analysis of 1HNMR, 13CNMR and MS.Isocalophyllic acid exhibited selective in vitro cytotoxicity toward Bel-7402 and NCI 4460, their IC50 were 9.074 and 6.372 μg/mL, respectively.

Key words: Calophyllum membranaceum Gardn.et Champ., isocalophyllic acid, cytotoxicity

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