顺-1,8-对烷二胺双酰胺杂环类衍生物的合成及抑菌活性研究

doi:10.3969/j.issn.0253-2417.2017.02.010

Abstract

Abstract: Using dichloroacetonitrile as solvent, Eight bis-alkanoyl-amines heterocyclic derivatives B1-B8 were synthesized through nucleophilic addition-elimination reaction of carboxylic acid chloride containing heterocycle and cis-1, 8-p-menthane diamine. And the yields of derivatives were 53%-100%. The structures of the products were characterized by FT-IR, ESI⁺-MS, ¹H NMR and ¹³C NMR. The antibacterial activities were determined, and the results showed that some products had excellent antibacterial activities against Staphylococcus aureus and Candida albicans. The minimum inhibitory concentration (MIC) of compound B8 against S. aureus and C. albicans were both 56.25 mg/L.

Key words: cis-1,8-p-menthane diamine, bis-alkanoyl-amines heterocyclic derivatives, synthesis, antibacterial activity

CLC Number:

TQ35

ZHU Shouji, YANG Xuebing, XU Shichao, ZHAO Zhendong, JIANG Jianxin. Synthesis and Antibacterial Activity of Bis-alkanoyl-amines Heterocyclic Derivatives of cis-1,8-p-Menthane Diamine[J]. Chemistry and Industry of Forest Products, 2017, 37(2): 79-84.

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Synthesis and Antibacterial Activity of Bis-alkanoyl-amines Heterocyclic Derivatives of cis-1,8-p-Menthane Diamine

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