Abstract: Polyprenols from Ginkgo biloba Linn. (GP) was made to get a purify of 87.3% by separating non-saponifialble matter of GP with means of saponification, solvent refrigeration and II-grade molecular distillation. Different models of mice planted with SF763 tumor, A549 tumor, and transplanted EC tumor respectively were built. The effects of GP on prolonging survival time of mice bearing tumors of SF763, A549 and Ec respectively were studied by treating with ADM and ACNU iv., CY ip.and polyprenols po..The results showed that GP(320 mg/kg) combined with ADM(2 mg/kg) could significantly prolong survival time of mice bearing SF763 tumor, the life-prolonging rate was 88% (P<0.01)in contrast to normal controls; GP (>40 mg/kg) significantly had a inhibition on A549(P<0.05), the optium dosage of GP was 80 mg/kg, which had an inhibition of 82.2%(P<0.01) after an inoculation of 11 days; GP had a negative relation on prolonging survival time of mice bearing EC tumors between dosage of GP and the effect. The optimum dosage was 5-10 mg/kg,which had optimum prolonging rate of 32.77%(P<0.05). Thus GP could significantly prolong survival time of mice bearing SF763, A549 and EC tumors.

Key words: Ginkgo biloba Linn., polyprenols, SF763, A549, EC, life-prolonging rate