姜黄素纳米混悬剂的制备及其表征

doi:10.3969/j.issn.0253-2417.2016.02.016

Abstract

Abstract: In order to improve the water solubility of curcumin, curcumin nanosuspensions were prepared by high pressure homogenization technology, and the preparation process was optimized.The physicochemical properties and chemical structure of curcumin nanosuspensions were investigated by UV spectrometry, infrared spectrometry (IR), X-ray diffractometry (XRD), transmission electron microscopy (TEM) and high performance liquid chromatography (HPLC). The results showed that the mean particle size of curcumin nanosuspension was (171.00±8.56)nm, and the PI was (0.69±0.05) under optimal conditions of 100 MPa and 30 cycles. UV, IR, XRD,TEM and HPLC results showed that the chemical structures of curcumin nanosuspensions were not obviously changed, the curcumin nanoparticles were irregular spherical form, and the crystallinity decreased. The water solubilities of curcumin nanopowder were 62.85 mg/L enhanced by 90.48 times compared with curcumin powder. The dissolution velocities were significantly improved, and the dissolution rate reached up to 80% at the time of 120 min. The research indicated that high pressure homogenization technology could be successfully used to prepare curcumin nanosuspensions.

Key words: curcumin nanosuspensions, high pressure homogenization, physicochemical property, preparation, characterization

CLC Number:

TQ35
TQ460.6

ZHANG Sheng-wei, LI Xiang-zhou, LI Wen-sheng, GU Sheng-hua. Preparation and Characterization of Curcumin Nanosuspensions[J]. Chemistry and Industry of Forest Products, 2016, 36(2): 109-114.

References

[1] 吴亚丽,谢俊霞,卢楠,等.姜黄素对结肠癌细胞增殖抑制和凋亡诱导的作用研究[J].现代食品科技,2014,30(4):74-79. WU Ya-li,XIE Jun-xia,LU Nan,et al.Effects of curcumin on proliferation and apoptosis of colorectal carcinoma LoVo cells[J].Modern Food Science & Technology,2014,30(4):74-79.
[2] MORIYUKI K,SEKIGUCHI F,MATSUBARA K,et al.Curcumin inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing cyclooxygenase-2 upregulation and akt-dependent activation of nuclear factor-κB in human lung epithelial cells[J].Journal of Pharmacological Sciences,2010,114(2):225-229.
[3] 旷春桃,李湘洲,薛海鹏,等.姜黄素衍生物的合成和生物活性研究[J].林产化学与工业,2014,34(5):67-72. KUANG Chun-tao,LI Xiang-zhou,XUE Hai-peng,et al.Synthesis and biological activity of curcumin derivatives[J].Chemistry and Industry of Forest Products,2014,34(5):67-72.
[4] TANG Hong-mei,LU Da-xiang,PAN Rui,et al.Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats[J].Life Sciences,2009,85(1/2):1-10.
[5] SA G,DAS T.Anti cancer effects of curcumin:Cycle of life and death[J].Cell Division,2008,3(1):14.
[6] 余美荣,蒋福升,丁志山.姜黄素的研究进展[J].中草药,2009,40(5):828-831. YU Mei-rong,JIANG Fu-sheng,DING Zhi-shan.Advances in studies on curcumin[J].Chinese Traditional and Herbal Drugs,2009,40(5):828-831.
[7] 潘艺茗.PLA/PLGA-姜黄素纳米粒的制备与性能研究[D].广州:华南理工大学硕士学位论文,2012. PAN Yi-ming.Research on preparation and properties of curcumin-loaded PLA/PLGA nanoparticles[D].Guangzhou:Master Degress Thesis of South China University of Technology,2012.
[8] KOCBEK P,BAUMGARTNER S,KRISTL J.Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs[J].International Journal of Pharmaceutics,2006,312(1/2):179-186.
[9] MÜLLER R H,PETERS K.Nanosuspensions for the formulation of poorly soluble drugs:I.Preparation by a size-reduction technique[J].International Journal of Pharmaceutics,1998,160(2):229-237.
[10] GRAU M J,KAYSER O,MÜLLER R H.Nanosuspensions of poorly soluble drugs-reproducibility of small scale production[J].International Journal of Pharmaceutics,2000,196(2):155-159.
[11] 王丽丽.多西他赛脂质纳米混悬剂的研究[D].济南:山东大学硕士学位论文,2012. WANG Li-li.Preliminary studies on docetaxel-lipid-based-nanosuspensions[D].Jinan:Master Degress Thesis of Shandong University,2012.
[12] 赵先英,刘毅敏,周小霞,等.度他雄胺纳米悬浮液的制备[J].西南国防医药,2013,23(12):1286-1288. ZHAO Xian-ying,LIU Yi-min,ZHOU Xiao-xia,et al.Preparation of dutasteride nanometer suspension[J].Medical Journal of National Defending Forces in Southwest China,2013,23(12):1286-1288.
[13] 国家药典委员会.中华人民共和国药典(二部)[M].北京:化学工业出版社,2005. State Pharmacopeia Committee of China.Chinese Pharmacopoeia:2nd[M].Beijing:Chemical Industry Press,2005.
[14] VAN EERDENBRUGH B,VAN DEN MOOTER G,AUGUSTIJNS P.Top-down production of drug nanocrystals:Nanosuspension stabilization,miniaturization and transformation into solid products[J].International Journal of Pharmaceutics,2008,364(1):64-75.
[15] SINHA S,ALI M,BABOOTA S,et al.Solid dispersion as an approach for bioavailability enhancement of poorly water-soluble drug ritonavir[J].AAPS PharmSciTech,2010,11(2):518-527.
[16] ZHONG Jie,SHEN Zhi-gang,YANG Yan,et al.Preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment[J].International Journal of Pharmaceutics,2005,301(1/2):286-293.

Preparation and Characterization of Curcumin Nanosuspensions

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