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Chemistry and Industry of Forest Products ›› 2019, Vol. 39 ›› Issue (6): 88-94.doi: 10.3969/j.issn.0253-2417.2019.06.012

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Chemical Constituents and Anti-inflammatory Activity from the Twigs of Euscaphis konishii Hayata

Jingxin CHEN1(),Yuying ZHAN1,Yan CHEN1,Huiyou XU1,Shuangquan ZOU2,Lin NI1,2,*()   

  1. 1. College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    2. Fujian Colleges and Universities Engineering Research Institute of Conservation & Utilization of Natural Bioresources, Fujian Agriculture and Forestry University, Fuzhou 350002, China
  • Received:2019-06-03 Online:2019-12-28 Published:2019-12-21
  • Contact: Lin NI E-mail:1336921733@qq.com;nilin_fjau@126.com
  • Supported by:


Fifteen compounds were isolated from the twigs of Euscaphis konishii Hayata.The structure of the compounds was identified by physico-chemical properties and spectral data, and the fifteen compounds were as follows:threo-1-(4-hdroxy-3-methoxyphenyl)-2[4-(4'-hydroxypropyl)-2'-methoxyphenoxy] -1, 3-propanediol(1), acernikol (2), nortrachelogenin-4-O-β-D-glucopyranoside (3), nortrachelogenin 4'-O-β-D-glucopyranoside (4), 2-[4-(1-hydroxypropyl)-3-methoxyphenoxy] -1, 3-propanediol (5), 5, 7-dihydroxy-2-methylchromanone (6), isobiflorin (7), biflorin (8), quercetin-3-O-α-L-arabinose (9), gallic acid (10), 4-hydroxy-3-methoxy benzaldehyde (11), stearic acid (12), 19α-hydroxy ursolic acid (13), β-sitosterol (14), daucosterol (15).All compounds except 7, 8, 14, 15 were isolated from the plants of the genus E. konishii for the first time.The evaluation results of anti-inflammatory activity showed that the inhibition rates of lipopolysaccharide-induced murine IL-6 secretion by compound 2 and 4 were (63.4±7.1)% and (58.6±4.6)%, respectively, at the concentration of 10 μmol/L.The medium inhibitory activity was shown to be slightly lower than that of the positive control drug dexamethasone.

Key words: Euscaphis konishii Hayata, chemical constituents, structures identification, IL-6

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