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林产化学与工业

林产化学与工业 ›› 2013, Vol. 33 ›› Issue (4): 53-56.doi: 10.3969/j.issn.0253-2417.2013.04.010

• 1研究报告 • 上一篇    下一篇

银杏叶聚戊烯醇及其衍生物的抑菌活性研究

周彦1,2, 王成章1, 李在均2   

  1. 1. 中国林业科学研究院林产化学工业研究所; 生物质化学利用国家工程实验室; 国家林业局林产化学工程重点开放性实验室; 江苏省生物质能源与材料重点实验室, 江苏 南京 210042;2. 江南大学化学与材料工程学院, 江苏 无锡 214122
  • 收稿日期:2012-05-30 修回日期:1900-01-01 出版日期:2013-08-30 发布日期:2013-08-30
  • 通讯作者: 王成章(1966- ),男,湖北汉川人,研究员,博士生导师,主要从事天然产物化学与应用研究;E-mail:wangczlhs@sina.com。

Antibacterial Activity of the Ginkgo biloba Polyprenols and Their Derivatives

ZHOU Yan1,2, WANG Cheng-zhang1, LI Zai-jun2   

  1. 1. Institute of Chemical Industry of Forestry Products, CAF; National Engineering Lab. for Biomass Chemical Utilization; Key and Open Lab. of Forest Chemical Engineering, SFA; Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China;2. School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
  • Received:2012-05-30 Revised:1900-01-01 Online:2013-08-30 Published:2013-08-30

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摘要： 以银杏叶聚戊烯醇为原料,通过酯化反应合成了聚戊烯基季铵盐、聚戊烯基磷酸钠以及聚戊烯基乙酸酯,并对其结构进行了表征。采用滤纸片法测定了银杏叶聚戊烯醇及其衍生物对于金黄色葡萄球菌(S. aureus)和大肠杆菌(E.coli)的抑菌圈直径,以等倍稀释法测定其最小抑菌浓度(MIC)值,并对其进行抗菌谱测试。结果表明,银杏叶聚戊烯醇衍生物对金黄色葡萄球菌和大肠杆菌的MIC值范围0.062 5~1g/L,低于银杏叶聚戊烯醇的MIC值范围2~4g/L,4种样品对于金黄色葡萄球菌和大肠杆菌均有较好的抑制作用,银杏叶聚戊烯醇的抑菌活性较其衍生物略低,4种样品对于枯草芽孢菌和沙门氏菌亦有抑制作用,对于啤酒酵母菌和黑曲霉菌无明显抑菌作用。

关键词: 抑菌, 银杏叶聚戊烯醇, 衍生物

Abstract: Ginkgo biloba polyprenols were used as raw material, three derivatives of Ginkgo biloba polyprenols that included polyprenyl sodium phosphate, polyprenyl acetate and polyprenyl ammonium salt were synthesized by esterification and the structures of the products were characterized. Diameters of inhibition zone to S.aureus and E.coli of Ginkgo biloba polyprenols and their derivatives were determined. The MICs of four samples were determined by coubling dilution and the antibacterial spectra were studied. The results indicated that the four samples displayed good antibacterial activities to S.aureus and E.coli, and the derivatives had stronger antibacterial activity than Ginko biloba polyprenols. Four samples also had antibacterial effect to B.subtilis and S.enterica but had hardly antibacterial effect to A.niger and S.cerevisiae.

Key words: antibacterial, Gingko biloba polyprenols, derivatives

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